ROS signaling in innate immunity via oxidative protein modifications
The innate immune response represents the first-line of defense against invading pathogens. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated in various aspects of innate immune function, which involves respiratory bursts and inflammasome activation. These reacti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359600/full |
| _version_ | 1797271445564293120 |
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| author | Renuka Ramalingam Manoharan Ankush Prasad Pavel Pospíšil Julia Kzhyshkowska Julia Kzhyshkowska Julia Kzhyshkowska Julia Kzhyshkowska |
| author_facet | Renuka Ramalingam Manoharan Ankush Prasad Pavel Pospíšil Julia Kzhyshkowska Julia Kzhyshkowska Julia Kzhyshkowska Julia Kzhyshkowska |
| author_sort | Renuka Ramalingam Manoharan |
| collection | DOAJ |
| description | The innate immune response represents the first-line of defense against invading pathogens. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated in various aspects of innate immune function, which involves respiratory bursts and inflammasome activation. These reactive species widely distributed within the cellular environment are short-lived intermediates that play a vital role in cellular signaling and proliferation and are likely to depend on their subcellular site of formation. NADPH oxidase complex of phagocytes is known to generate superoxide anion radical (O2•−) that functions as a precursor for antimicrobial hydrogen peroxide (H2O2) production, and H2O2 is utilized by myeloperoxidase (MPO) to generate hypochlorous acid (HOCl) that mediates pathogen killing. H2O2 modulates the expression of redox-responsive transcriptional factors, namely NF-kB, NRF2, and HIF-1, thereby mediating redox-based epigenetic modification. Survival and function of immune cells are under redox control and depend on intracellular and extracellular levels of ROS/RNS. The current review focuses on redox factors involved in the activation of immune response and the role of ROS in oxidative modification of proteins in macrophage polarization and neutrophil function. |
| first_indexed | 2024-03-07T14:02:50Z |
| format | Article |
| id | doaj.art-3984fe8f1d8548f3a7dfbf2effa7ae1f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T14:02:50Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3984fe8f1d8548f3a7dfbf2effa7ae1f2024-03-07T04:27:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13596001359600ROS signaling in innate immunity via oxidative protein modificationsRenuka Ramalingam Manoharan0Ankush Prasad1Pavel Pospíšil2Julia Kzhyshkowska3Julia Kzhyshkowska4Julia Kzhyshkowska5Julia Kzhyshkowska6Department of Biophysics, Faculty of Science, Palacký University, Olomouc, CzechiaDepartment of Biophysics, Faculty of Science, Palacký University, Olomouc, CzechiaDepartment of Biophysics, Faculty of Science, Palacký University, Olomouc, CzechiaInstitute of Transfusion Medicine and Immunology, Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyGerman Red Cross Blood Service Baden-Württemberg - Hessen, Mannheim, GermanyLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, Tomsk, RussiaLaboratory of Genetic Technologies, Siberian State Medical University, Tomsk, RussiaThe innate immune response represents the first-line of defense against invading pathogens. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated in various aspects of innate immune function, which involves respiratory bursts and inflammasome activation. These reactive species widely distributed within the cellular environment are short-lived intermediates that play a vital role in cellular signaling and proliferation and are likely to depend on their subcellular site of formation. NADPH oxidase complex of phagocytes is known to generate superoxide anion radical (O2•−) that functions as a precursor for antimicrobial hydrogen peroxide (H2O2) production, and H2O2 is utilized by myeloperoxidase (MPO) to generate hypochlorous acid (HOCl) that mediates pathogen killing. H2O2 modulates the expression of redox-responsive transcriptional factors, namely NF-kB, NRF2, and HIF-1, thereby mediating redox-based epigenetic modification. Survival and function of immune cells are under redox control and depend on intracellular and extracellular levels of ROS/RNS. The current review focuses on redox factors involved in the activation of immune response and the role of ROS in oxidative modification of proteins in macrophage polarization and neutrophil function.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359600/fulloxidative stressreactive oxygen speciesinflammationinnate immune responsemacrophageneutrophils |
| spellingShingle | Renuka Ramalingam Manoharan Ankush Prasad Pavel Pospíšil Julia Kzhyshkowska Julia Kzhyshkowska Julia Kzhyshkowska Julia Kzhyshkowska ROS signaling in innate immunity via oxidative protein modifications Frontiers in Immunology oxidative stress reactive oxygen species inflammation innate immune response macrophage neutrophils |
| title | ROS signaling in innate immunity via oxidative protein modifications |
| title_full | ROS signaling in innate immunity via oxidative protein modifications |
| title_fullStr | ROS signaling in innate immunity via oxidative protein modifications |
| title_full_unstemmed | ROS signaling in innate immunity via oxidative protein modifications |
| title_short | ROS signaling in innate immunity via oxidative protein modifications |
| title_sort | ros signaling in innate immunity via oxidative protein modifications |
| topic | oxidative stress reactive oxygen species inflammation innate immune response macrophage neutrophils |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359600/full |
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