Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology
In the last few years, vitamin D functions have been studied progressively, and along with their main role in regulating calcium homeostasis, the potential function in the nervous system and the link between different psychiatric disorders and vitamin D deficiency have been revealed. The discovery o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/12/2056 |
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| author | Adela Magdalena Ciobanu Cristian Petrescu Cristina Anghele Mihnea Costin Manea Constantin Alexandru Ciobanu Diana Mihaela Petrescu Mihalache Oana Antonia Sorin Riga |
| author_facet | Adela Magdalena Ciobanu Cristian Petrescu Cristina Anghele Mihnea Costin Manea Constantin Alexandru Ciobanu Diana Mihaela Petrescu Mihalache Oana Antonia Sorin Riga |
| author_sort | Adela Magdalena Ciobanu |
| collection | DOAJ |
| description | In the last few years, vitamin D functions have been studied progressively, and along with their main role in regulating calcium homeostasis, the potential function in the nervous system and the link between different psychiatric disorders and vitamin D deficiency have been revealed. The discovery of vitamin D receptors in multiple brain structures, like the hippocampus, led to the hypothesis that vitamin D deficiency could be responsible for treatment resistance in psychiatric diseases. The aim of this study was to analyze the current knowledge in the literature regarding vitamin D deficiency among individuals afflicted with psychiatric disorders and assess the potential therapeutic benefits of vitamin D supplementation. A systematic search was conducted on the PubMed database for articles published in the last five years (2016–2022) in English, focusing on human subjects. Results show that vitamin D deficiency has implications for numerous psychiatric disorders, affecting mood and behavior through its influence on neurotransmitter release, neurotrophic factors, and neuroprotection. It also plays a role in modulating inflammation, which is often elevated in psychiatric disorders. In conclusion, vitamin D deficiency is prevalent and has far-reaching implications for mental health. This review underscores the importance of exploring the therapeutic potential of vitamin D supplementation in individuals with psychiatric disorders and highlights the need for further research in this complex field. |
| first_indexed | 2024-03-08T20:33:42Z |
| format | Article |
| id | doaj.art-398613e02ecc480f90a7527182fc5527 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-08T20:33:42Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-398613e02ecc480f90a7527182fc55272023-12-22T14:23:39ZengMDPI AGMedicina1010-660X1648-91442023-11-015912205610.3390/medicina59122056Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric PathologyAdela Magdalena Ciobanu0Cristian Petrescu1Cristina Anghele2Mihnea Costin Manea3Constantin Alexandru Ciobanu4Diana Mihaela Petrescu5Mihalache Oana Antonia6Sorin Riga7Neuroscience Department, Discipline of Psychiatry, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaNeuroscience Department, Discipline of Psychiatry, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaNeuroscience Department, Discipline of Psychiatry, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaNeuroscience Department, Discipline of Psychiatry, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, 020022 Bucharest, RomaniaDepartment of Neurology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaNeurology Clinic, “Fundeni” Clinical Institute, 022328 Bucharest, RomaniaDepartment of Stress Research and Prophylaxis, “Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, 041914 Bucharest, RomaniaIn the last few years, vitamin D functions have been studied progressively, and along with their main role in regulating calcium homeostasis, the potential function in the nervous system and the link between different psychiatric disorders and vitamin D deficiency have been revealed. The discovery of vitamin D receptors in multiple brain structures, like the hippocampus, led to the hypothesis that vitamin D deficiency could be responsible for treatment resistance in psychiatric diseases. The aim of this study was to analyze the current knowledge in the literature regarding vitamin D deficiency among individuals afflicted with psychiatric disorders and assess the potential therapeutic benefits of vitamin D supplementation. A systematic search was conducted on the PubMed database for articles published in the last five years (2016–2022) in English, focusing on human subjects. Results show that vitamin D deficiency has implications for numerous psychiatric disorders, affecting mood and behavior through its influence on neurotransmitter release, neurotrophic factors, and neuroprotection. It also plays a role in modulating inflammation, which is often elevated in psychiatric disorders. In conclusion, vitamin D deficiency is prevalent and has far-reaching implications for mental health. This review underscores the importance of exploring the therapeutic potential of vitamin D supplementation in individuals with psychiatric disorders and highlights the need for further research in this complex field.https://www.mdpi.com/1648-9144/59/12/2056vitamin D deficiencymental healthdepressiondepressive symptomsanxietymood |
| spellingShingle | Adela Magdalena Ciobanu Cristian Petrescu Cristina Anghele Mihnea Costin Manea Constantin Alexandru Ciobanu Diana Mihaela Petrescu Mihalache Oana Antonia Sorin Riga Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology Medicina vitamin D deficiency mental health depression depressive symptoms anxiety mood |
| title | Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology |
| title_full | Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology |
| title_fullStr | Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology |
| title_full_unstemmed | Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology |
| title_short | Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology |
| title_sort | severe vitamin d deficiency a possible cause of resistance to treatment in psychiatric pathology |
| topic | vitamin D deficiency mental health depression depressive symptoms anxiety mood |
| url | https://www.mdpi.com/1648-9144/59/12/2056 |
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