Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women
Abstract Background Obesity is considered problematic not only as a major cause of diabetes, hypertension, and dyslipidemia, but also as a risk of intractable dermatosis; however influence of obesity on skin function has not been clarified. To clarify the mechanism of obesity-associated skin disorde...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-017-0608-1 |
| _version_ | 1818033574191824896 |
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| author | Shinobu Mori Akiko Shiraishi Karen Epplen Desiree Butcher Daiki Murase Yuka Yasuda Takatoshi Murase |
| author_facet | Shinobu Mori Akiko Shiraishi Karen Epplen Desiree Butcher Daiki Murase Yuka Yasuda Takatoshi Murase |
| author_sort | Shinobu Mori |
| collection | DOAJ |
| description | Abstract Background Obesity is considered problematic not only as a major cause of diabetes, hypertension, and dyslipidemia, but also as a risk of intractable dermatosis; however influence of obesity on skin function has not been clarified. To clarify the mechanism of obesity-associated skin disorders, we aimed to characterize the skin function of subjects with obesity, and identify possible influencing factors. Methods Complex analyses including instrumental measurement, biochemical and lipidomics were performed for facial skin and physical evaluation in 93 Caucasian women with obesity (OB) and non-obesity (NOB). Results In OB, imbalance in metabolism of carbohydrate and lipid, autonomic nerve activity, and secreted factors were confirmed. In the skin properties in OB, surface roughness was higher by 70%, the water content was lower by 12%, and changes in the lipid profile of stratum corneum ceramide were observed; in particular, a 7% reduction of [NP]-type ceramide, compared with NOB. Moreover, significant redness accompanied by a 34% increase in skin blood flow was observed in OB. Correlation analysis elucidated that the water content was strongly correlated with local skin indices, such as the ceramide composition, redness, blood flow, and TNFα in the stratum corneum, whereas roughness was correlated with the systemic indices, such as serum insulin, leptin, and IL-6. Conclusions Characteristics of obesity-associated skin were (A) reduction of the barrier and moisturizing function accompanied by intercellular lipid imbalance, (B) increased redness accompanied by hemodynamic changes, and (C) surface roughness. It was suggested that each symptom is due to different causes in local and/or systemic physiological impairment related to the autonomic nerve-vascular system, inflammation and insulin resistance. |
| first_indexed | 2024-12-10T06:25:26Z |
| format | Article |
| id | doaj.art-398635e96f3a4f68927a1f6efcc0b8dc |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-10T06:25:26Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-398635e96f3a4f68927a1f6efcc0b8dc2022-12-22T01:59:13ZengBMCLipids in Health and Disease1476-511X2017-11-0116111110.1186/s12944-017-0608-1Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American womenShinobu Mori0Akiko Shiraishi1Karen Epplen2Desiree Butcher3Daiki Murase4Yuka Yasuda5Takatoshi Murase6Biological Science Laboratories, Kao CorporationBiological Science Laboratories, Kao CorporationSpring Grove LaboratoriesSpring Grove LaboratoriesBiological Science Laboratories, Kao CorporationAnalysis Science Laboratories, Kao CorporationBiological Science Laboratories, Kao CorporationAbstract Background Obesity is considered problematic not only as a major cause of diabetes, hypertension, and dyslipidemia, but also as a risk of intractable dermatosis; however influence of obesity on skin function has not been clarified. To clarify the mechanism of obesity-associated skin disorders, we aimed to characterize the skin function of subjects with obesity, and identify possible influencing factors. Methods Complex analyses including instrumental measurement, biochemical and lipidomics were performed for facial skin and physical evaluation in 93 Caucasian women with obesity (OB) and non-obesity (NOB). Results In OB, imbalance in metabolism of carbohydrate and lipid, autonomic nerve activity, and secreted factors were confirmed. In the skin properties in OB, surface roughness was higher by 70%, the water content was lower by 12%, and changes in the lipid profile of stratum corneum ceramide were observed; in particular, a 7% reduction of [NP]-type ceramide, compared with NOB. Moreover, significant redness accompanied by a 34% increase in skin blood flow was observed in OB. Correlation analysis elucidated that the water content was strongly correlated with local skin indices, such as the ceramide composition, redness, blood flow, and TNFα in the stratum corneum, whereas roughness was correlated with the systemic indices, such as serum insulin, leptin, and IL-6. Conclusions Characteristics of obesity-associated skin were (A) reduction of the barrier and moisturizing function accompanied by intercellular lipid imbalance, (B) increased redness accompanied by hemodynamic changes, and (C) surface roughness. It was suggested that each symptom is due to different causes in local and/or systemic physiological impairment related to the autonomic nerve-vascular system, inflammation and insulin resistance.http://link.springer.com/article/10.1186/s12944-017-0608-1ObesitySkin functionInsulin resistanceInflammation |
| spellingShingle | Shinobu Mori Akiko Shiraishi Karen Epplen Desiree Butcher Daiki Murase Yuka Yasuda Takatoshi Murase Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women Lipids in Health and Disease Obesity Skin function Insulin resistance Inflammation |
| title | Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women |
| title_full | Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women |
| title_fullStr | Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women |
| title_full_unstemmed | Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women |
| title_short | Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women |
| title_sort | characterization of skin function associated with obesity and specific correlation to local systemic parameters in american women |
| topic | Obesity Skin function Insulin resistance Inflammation |
| url | http://link.springer.com/article/10.1186/s12944-017-0608-1 |
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