Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock
Abstract Background Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on the septic myocardium remain unclear. The aim of the study was to compare the effects of angiotensin II and norepinephrine on cardiac function and myocardial oxygen consumption, i...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Critical Care |
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| Online Access: | https://doi.org/10.1186/s13054-022-04161-3 |
| _version_ | 1798000705423802368 |
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| author | Bruno Garcia Fuhong Su Laurence Dewachter Raphaël Favory Amina Khaldi Alexander Moiroux-Sahraoui Filippo Annoni Francisco Vasques-Nóvoa Estela Rocha-Oliveira Roberto Roncon-Albuquerque Geraldine Hubesch Hassane Njimi Jean-Louis Vincent Fabio S. Taccone Jacques Creteur Antoine Herpain |
| author_facet | Bruno Garcia Fuhong Su Laurence Dewachter Raphaël Favory Amina Khaldi Alexander Moiroux-Sahraoui Filippo Annoni Francisco Vasques-Nóvoa Estela Rocha-Oliveira Roberto Roncon-Albuquerque Geraldine Hubesch Hassane Njimi Jean-Louis Vincent Fabio S. Taccone Jacques Creteur Antoine Herpain |
| author_sort | Bruno Garcia |
| collection | DOAJ |
| description | Abstract Background Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on the septic myocardium remain unclear. The aim of the study was to compare the effects of angiotensin II and norepinephrine on cardiac function and myocardial oxygen consumption, inflammation and injury in experimental septic shock. Methods This randomized, open-label, controlled study was performed in 20 anesthetized and mechanically ventilated pigs. Septic shock was induced by fecal peritonitis in 16 animals, and four pigs served as shams. Resuscitation with fluids, antimicrobial therapy and abdominal drainage was initiated one hour after the onset of septic shock. Septic pigs were randomly allocated to receive one of the two drugs to maintain mean arterial pressure between 65 and 75 mmHg for 8 h. Results There were no differences in MAP, cardiac output, heart rate, fluid balance or tissue perfusion indices in the two treatment groups but myocardial oxygen consumption was greater in the norepinephrine-treated animals. Myocardial mRNA expression of interleukin-6, interleukin-6 receptor, interleukin-1 alpha, and interleukin-1 beta was higher in the norepinephrine than in the angiotensin II group. Conclusions In septic shock, angiotensin II administration is associated with a similar level of cardiovascular resuscitation and less myocardial oxygen consumption, and inflammation compared to norepinephrine. |
| first_indexed | 2024-04-11T11:24:40Z |
| format | Article |
| id | doaj.art-39891891ee944cc9803ba90e223d342e |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-04-11T11:24:40Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-39891891ee944cc9803ba90e223d342e2022-12-22T04:26:20ZengBMCCritical Care1364-85352022-09-0126111310.1186/s13054-022-04161-3Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shockBruno Garcia0Fuhong Su1Laurence Dewachter2Raphaël Favory3Amina Khaldi4Alexander Moiroux-Sahraoui5Filippo Annoni6Francisco Vasques-Nóvoa7Estela Rocha-Oliveira8Roberto Roncon-Albuquerque9Geraldine Hubesch10Hassane Njimi11Jean-Louis Vincent12Fabio S. Taccone13Jacques Creteur14Antoine Herpain15Experimental Laboratory of Intensive Care, Université Libre de BruxellesExperimental Laboratory of Intensive Care, Université Libre de BruxellesLaboratory of Physiology and Pharmacology, Université Libre de BruxellesDepartment of Intensive Care, Centre Hospitalier Universitaire de LilleExperimental Laboratory of Intensive Care, Université Libre de BruxellesExperimental Laboratory of Intensive Care, Université Libre de BruxellesExperimental Laboratory of Intensive Care, Université Libre de BruxellesCardiovascular R&D Center, Faculty of Medicine, University of PortoCardiovascular R&D Center, Faculty of Medicine, University of PortoCardiovascular R&D Center, Faculty of Medicine, University of PortoLaboratory of Physiology and Pharmacology, Université Libre de BruxellesDepartment of Intensive Care, Erasme University Hospital, Université Libre de BruxellesExperimental Laboratory of Intensive Care, Université Libre de BruxellesExperimental Laboratory of Intensive Care, Université Libre de BruxellesExperimental Laboratory of Intensive Care, Université Libre de BruxellesExperimental Laboratory of Intensive Care, Université Libre de BruxellesAbstract Background Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on the septic myocardium remain unclear. The aim of the study was to compare the effects of angiotensin II and norepinephrine on cardiac function and myocardial oxygen consumption, inflammation and injury in experimental septic shock. Methods This randomized, open-label, controlled study was performed in 20 anesthetized and mechanically ventilated pigs. Septic shock was induced by fecal peritonitis in 16 animals, and four pigs served as shams. Resuscitation with fluids, antimicrobial therapy and abdominal drainage was initiated one hour after the onset of septic shock. Septic pigs were randomly allocated to receive one of the two drugs to maintain mean arterial pressure between 65 and 75 mmHg for 8 h. Results There were no differences in MAP, cardiac output, heart rate, fluid balance or tissue perfusion indices in the two treatment groups but myocardial oxygen consumption was greater in the norepinephrine-treated animals. Myocardial mRNA expression of interleukin-6, interleukin-6 receptor, interleukin-1 alpha, and interleukin-1 beta was higher in the norepinephrine than in the angiotensin II group. Conclusions In septic shock, angiotensin II administration is associated with a similar level of cardiovascular resuscitation and less myocardial oxygen consumption, and inflammation compared to norepinephrine.https://doi.org/10.1186/s13054-022-04161-3Septic shockSeptic cardiomyopathyVasopressorsInflammationRenin-angiotensin system |
| spellingShingle | Bruno Garcia Fuhong Su Laurence Dewachter Raphaël Favory Amina Khaldi Alexander Moiroux-Sahraoui Filippo Annoni Francisco Vasques-Nóvoa Estela Rocha-Oliveira Roberto Roncon-Albuquerque Geraldine Hubesch Hassane Njimi Jean-Louis Vincent Fabio S. Taccone Jacques Creteur Antoine Herpain Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock Critical Care Septic shock Septic cardiomyopathy Vasopressors Inflammation Renin-angiotensin system |
| title | Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock |
| title_full | Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock |
| title_fullStr | Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock |
| title_full_unstemmed | Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock |
| title_short | Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock |
| title_sort | myocardial effects of angiotensin ii compared to norepinephrine in an animal model of septic shock |
| topic | Septic shock Septic cardiomyopathy Vasopressors Inflammation Renin-angiotensin system |
| url | https://doi.org/10.1186/s13054-022-04161-3 |
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