Moving towards system genetics through multiple trait analysis in genome-wide association studies
Association studies are a staple of genotype-phenotype mapping studies, whether they are based on single markers, haplotypes, candidate genes, genome-wide genotypes, or whole genome sequences. Although genetic epidemiological studies typically contain data collected on multiple traits which themselv...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00001/full |
| _version_ | 1818454731701354496 |
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| author | Daniel eShriner |
| author_facet | Daniel eShriner |
| author_sort | Daniel eShriner |
| collection | DOAJ |
| description | Association studies are a staple of genotype-phenotype mapping studies, whether they are based on single markers, haplotypes, candidate genes, genome-wide genotypes, or whole genome sequences. Although genetic epidemiological studies typically contain data collected on multiple traits which themselves are often correlated, most analyses have been performed on single traits. Here, I review several methods that have been developed to perform multiple trait analysis. These methods range from traditional multivariate models for systems of equations to recently developed graphical approaches based on network theory. The application of network theory to genetics is termed systems genetics and has the potential to address long-standing questions in genetics about complex processes such as coordinate regulation, homeostasis, and pleiotropy. |
| first_indexed | 2024-12-14T21:59:33Z |
| format | Article |
| id | doaj.art-39896cdd43ec4fbcb3eeaa96244f4a95 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-14T21:59:33Z |
| publishDate | 2012-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-39896cdd43ec4fbcb3eeaa96244f4a952022-12-21T22:46:02ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-01-01310.3389/fgene.2012.0000118480Moving towards system genetics through multiple trait analysis in genome-wide association studiesDaniel eShriner0National Human Genome Research InstituteAssociation studies are a staple of genotype-phenotype mapping studies, whether they are based on single markers, haplotypes, candidate genes, genome-wide genotypes, or whole genome sequences. Although genetic epidemiological studies typically contain data collected on multiple traits which themselves are often correlated, most analyses have been performed on single traits. Here, I review several methods that have been developed to perform multiple trait analysis. These methods range from traditional multivariate models for systems of equations to recently developed graphical approaches based on network theory. The application of network theory to genetics is termed systems genetics and has the potential to address long-standing questions in genetics about complex processes such as coordinate regulation, homeostasis, and pleiotropy.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00001/fullmultivariate analysispleiotropySystems genetics |
| spellingShingle | Daniel eShriner Moving towards system genetics through multiple trait analysis in genome-wide association studies Frontiers in Genetics multivariate analysis pleiotropy Systems genetics |
| title | Moving towards system genetics through multiple trait analysis in genome-wide association studies |
| title_full | Moving towards system genetics through multiple trait analysis in genome-wide association studies |
| title_fullStr | Moving towards system genetics through multiple trait analysis in genome-wide association studies |
| title_full_unstemmed | Moving towards system genetics through multiple trait analysis in genome-wide association studies |
| title_short | Moving towards system genetics through multiple trait analysis in genome-wide association studies |
| title_sort | moving towards system genetics through multiple trait analysis in genome wide association studies |
| topic | multivariate analysis pleiotropy Systems genetics |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00001/full |
| work_keys_str_mv | AT danieleshriner movingtowardssystemgeneticsthroughmultipletraitanalysisingenomewideassociationstudies |