Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges

Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges

Oligodendrocytes and their precursors are the cells responsible for developmental myelination and myelin repair during adulthood. Their differentiation and maturation processes are regulated by a complex molecular machinery driven mainly by triiodothyronine (T3), the genomic active form of thyroid h...

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Bibliographic Details
Main Authors: Vito Antonio Baldassarro, Corinne Quadalti, Massimiliano Runfola, Clementina Manera, Simona Rapposelli, Laura Calzà
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceuticals
Subjects:
thyroid hormone receptors
oligodendrocyte precursor cells
TG68
thyromimetics
inflammation
Online Access:https://www.mdpi.com/1424-8247/16/9/1207

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