DIABETIC CARDIOMYOPATHY. RESISTIN: A CONTROL OF A MYOCARDIAL HYPERTROPHY
<p><strong>Aim.</strong> To evaluate the association of serum resistin with morphological and functional indices of hypertrophic myocardium in patients with type 2 diabetes and chronic heart failure (CHF) with preserved left ventricular ejection fraction.</p><p><stro...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | http://www.rpcardio.ru/jour/article/view/214 |
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| author | An. A. Aleksandrov O. A. Shatskaya S. S. Kuharenko M. N. Yadrihinskaya E. N. Abdalkina E. N. Drozdova M. V. Shestakova |
| author_facet | An. A. Aleksandrov O. A. Shatskaya S. S. Kuharenko M. N. Yadrihinskaya E. N. Abdalkina E. N. Drozdova M. V. Shestakova |
| author_sort | An. A. Aleksandrov |
| collection | DOAJ |
| description | <p><strong>Aim.</strong> To evaluate the association of serum resistin with morphological and functional indices of hypertrophic myocardium in patients with type 2 diabetes and chronic heart failure (CHF) with preserved left ventricular ejection fraction.</p><p><strong>Material and methods.</strong> Patients (n=60; 12 men and 48 women) with type 2 diabetes and ischemic heart disease and CHF class II-III (NYHA) were included into the study. Clinical, laboratory and instrumental examinations, as well as determination of serum resistin were performed in all patients.</p><p><strong>Results.</strong> Positive correlation was found between serum resistin level and left ventricle end-diastolic pressure (LV EDP; r=0.43; p=0.02) in patients with concentric left ventricular hypertrophy (LVH). Negative correlation was found between serum resistin level and LV EDP (r=-0.61; p=0.000) in patients with eccentric LVH. A number of supraventricular extrasystoles positively correlated with the serum resistin level (r=0.34; p=0.033) in patients with concentric LVH.</p><p><strong>Conclusion.</strong> The role of "physiological" levels of resistin in the formation of cardiovascular indicators of the hypertrophic myocardium as well as possible prognostic significance of different levels of resistin for optimization of therapy are shown in patients with type 2 diabetes with CHF.</p> |
| first_indexed | 2024-03-12T09:06:31Z |
| format | Article |
| id | doaj.art-398b9f0622da491ab82b2ad76ec799ba |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T09:06:31Z |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-398b9f0622da491ab82b2ad76ec799ba2023-09-02T15:14:13ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-0110553453910.1234/1819-6446-2014-5-534-539214DIABETIC CARDIOMYOPATHY. RESISTIN: A CONTROL OF A MYOCARDIAL HYPERTROPHYAn. A. Aleksandrov0O. A. Shatskaya1S. S. Kuharenko2M. N. Yadrihinskaya3E. N. Abdalkina4E. N. Drozdova5M. V. Shestakova6Эндокринологический Научный ЦентрЭндокринологический Научный ЦентрЭндокринологический Научный ЦентрЭндокринологический Научный ЦентрСамарский Медицинский институт «Реавиз»Эндокринологический Научный ЦентрЭндокринологический Научный Центр<p><strong>Aim.</strong> To evaluate the association of serum resistin with morphological and functional indices of hypertrophic myocardium in patients with type 2 diabetes and chronic heart failure (CHF) with preserved left ventricular ejection fraction.</p><p><strong>Material and methods.</strong> Patients (n=60; 12 men and 48 women) with type 2 diabetes and ischemic heart disease and CHF class II-III (NYHA) were included into the study. Clinical, laboratory and instrumental examinations, as well as determination of serum resistin were performed in all patients.</p><p><strong>Results.</strong> Positive correlation was found between serum resistin level and left ventricle end-diastolic pressure (LV EDP; r=0.43; p=0.02) in patients with concentric left ventricular hypertrophy (LVH). Negative correlation was found between serum resistin level and LV EDP (r=-0.61; p=0.000) in patients with eccentric LVH. A number of supraventricular extrasystoles positively correlated with the serum resistin level (r=0.34; p=0.033) in patients with concentric LVH.</p><p><strong>Conclusion.</strong> The role of "physiological" levels of resistin in the formation of cardiovascular indicators of the hypertrophic myocardium as well as possible prognostic significance of different levels of resistin for optimization of therapy are shown in patients with type 2 diabetes with CHF.</p>http://www.rpcardio.ru/jour/article/view/214диабетическая кардиомиопатиярезистингипертрофией левого желудочка |
| spellingShingle | An. A. Aleksandrov O. A. Shatskaya S. S. Kuharenko M. N. Yadrihinskaya E. N. Abdalkina E. N. Drozdova M. V. Shestakova DIABETIC CARDIOMYOPATHY. RESISTIN: A CONTROL OF A MYOCARDIAL HYPERTROPHY Рациональная фармакотерапия в кардиологии диабетическая кардиомиопатия резистин гипертрофией левого желудочка |
| title | DIABETIC CARDIOMYOPATHY. RESISTIN: A CONTROL OF A MYOCARDIAL HYPERTROPHY |
| title_full | DIABETIC CARDIOMYOPATHY. RESISTIN: A CONTROL OF A MYOCARDIAL HYPERTROPHY |
| title_fullStr | DIABETIC CARDIOMYOPATHY. RESISTIN: A CONTROL OF A MYOCARDIAL HYPERTROPHY |
| title_full_unstemmed | DIABETIC CARDIOMYOPATHY. RESISTIN: A CONTROL OF A MYOCARDIAL HYPERTROPHY |
| title_short | DIABETIC CARDIOMYOPATHY. RESISTIN: A CONTROL OF A MYOCARDIAL HYPERTROPHY |
| title_sort | diabetic cardiomyopathy resistin a control of a myocardial hypertrophy |
| topic | диабетическая кардиомиопатия резистин гипертрофией левого желудочка |
| url | http://www.rpcardio.ru/jour/article/view/214 |
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