Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study
IntroductionHow the human brain coordinates bimanual movements is not well-established.MethodsHere, we recorded neural signals from a paralyzed individual’s left motor cortex during both unimanual and bimanual motor imagery tasks and quantified the representational interaction between arms by analyz...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1133928/full |
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| author | Dongrong Lai Dongrong Lai Dongrong Lai Zijun Wan Zijun Wan Zijun Wan Jiafan Lin Jiafan Lin Jiafan Lin Li Pan Li Pan Li Pan Feixiao Ren Feixiao Ren Junming Zhu Junming Zhu Jianmin Zhang Jianmin Zhang Yueming Wang Yueming Wang Yueming Wang Yaoyao Hao Yaoyao Hao Yaoyao Hao Kedi Xu Kedi Xu Kedi Xu Kedi Xu |
| author_facet | Dongrong Lai Dongrong Lai Dongrong Lai Zijun Wan Zijun Wan Zijun Wan Jiafan Lin Jiafan Lin Jiafan Lin Li Pan Li Pan Li Pan Feixiao Ren Feixiao Ren Junming Zhu Junming Zhu Jianmin Zhang Jianmin Zhang Yueming Wang Yueming Wang Yueming Wang Yaoyao Hao Yaoyao Hao Yaoyao Hao Kedi Xu Kedi Xu Kedi Xu Kedi Xu |
| author_sort | Dongrong Lai |
| collection | DOAJ |
| description | IntroductionHow the human brain coordinates bimanual movements is not well-established.MethodsHere, we recorded neural signals from a paralyzed individual’s left motor cortex during both unimanual and bimanual motor imagery tasks and quantified the representational interaction between arms by analyzing the tuning parameters of each neuron.ResultsWe found a similar proportion of neurons preferring each arm during unimanual movements, however, when switching to bimanual movements, the proportion of contralateral preference increased to 71.8%, indicating contralateral lateralization. We also observed a decorrelation process for each arm’s representation across the unimanual and bimanual tasks. We further confined that these changes in bilateral relationships are mainly caused by the alteration of tuning parameters, such as the increased bilateral preferred direction (PD) shifts and the significant suppression in bilateral modulation depths (MDs), especially the ipsilateral side.DiscussionThese results contribute to the knowledge of bimanual coordination and thus the design of cutting-edge bimanual brain-computer interfaces. |
| first_indexed | 2024-04-10T06:31:41Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T06:31:41Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-398bfbab596b4d84b77afa79d55cd4dd2023-03-01T06:14:00ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-03-011710.3389/fnins.2023.11339281133928Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot studyDongrong Lai0Dongrong Lai1Dongrong Lai2Zijun Wan3Zijun Wan4Zijun Wan5Jiafan Lin6Jiafan Lin7Jiafan Lin8Li Pan9Li Pan10Li Pan11Feixiao Ren12Feixiao Ren13Junming Zhu14Junming Zhu15Jianmin Zhang16Jianmin Zhang17Yueming Wang18Yueming Wang19Yueming Wang20Yaoyao Hao21Yaoyao Hao22Yaoyao Hao23Kedi Xu24Kedi Xu25Kedi Xu26Kedi Xu27Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, ChinaKey Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, ChinaQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, ChinaKey Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, ChinaQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, ChinaKey Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, ChinaQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, ChinaKey Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, ChinaQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, ChinaCollege of Computer Science and Technology, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, ChinaQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, ChinaCollege of Computer Science and Technology, Zhejiang University, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, ChinaCollege of Computer Science and Technology, Zhejiang University, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, ChinaQiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, ChinaKey Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, ChinaIntroductionHow the human brain coordinates bimanual movements is not well-established.MethodsHere, we recorded neural signals from a paralyzed individual’s left motor cortex during both unimanual and bimanual motor imagery tasks and quantified the representational interaction between arms by analyzing the tuning parameters of each neuron.ResultsWe found a similar proportion of neurons preferring each arm during unimanual movements, however, when switching to bimanual movements, the proportion of contralateral preference increased to 71.8%, indicating contralateral lateralization. We also observed a decorrelation process for each arm’s representation across the unimanual and bimanual tasks. We further confined that these changes in bilateral relationships are mainly caused by the alteration of tuning parameters, such as the increased bilateral preferred direction (PD) shifts and the significant suppression in bilateral modulation depths (MDs), especially the ipsilateral side.DiscussionThese results contribute to the knowledge of bimanual coordination and thus the design of cutting-edge bimanual brain-computer interfaces.https://www.frontiersin.org/articles/10.3389/fnins.2023.1133928/fullmotor imagerybrain-computer interface (BCI)primary motor cortex (M1)bimanual arm movementneuronal representation |
| spellingShingle | Dongrong Lai Dongrong Lai Dongrong Lai Zijun Wan Zijun Wan Zijun Wan Jiafan Lin Jiafan Lin Jiafan Lin Li Pan Li Pan Li Pan Feixiao Ren Feixiao Ren Junming Zhu Junming Zhu Jianmin Zhang Jianmin Zhang Yueming Wang Yueming Wang Yueming Wang Yaoyao Hao Yaoyao Hao Yaoyao Hao Kedi Xu Kedi Xu Kedi Xu Kedi Xu Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study Frontiers in Neuroscience motor imagery brain-computer interface (BCI) primary motor cortex (M1) bimanual arm movement neuronal representation |
| title | Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study |
| title_full | Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study |
| title_fullStr | Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study |
| title_full_unstemmed | Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study |
| title_short | Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study |
| title_sort | neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human a pilot study |
| topic | motor imagery brain-computer interface (BCI) primary motor cortex (M1) bimanual arm movement neuronal representation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1133928/full |
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