Brief bursts self-inhibit and correlate the pyramidal network.

Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the intricate manner in which they interconnect...

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Main Authors: Thomas K Berger, Gilad Silberberg, Rodrigo Perin, Henry Markram
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20838653/pdf/?tool=EBI
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author Thomas K Berger
Gilad Silberberg
Rodrigo Perin
Henry Markram
author_facet Thomas K Berger
Gilad Silberberg
Rodrigo Perin
Henry Markram
author_sort Thomas K Berger
collection DOAJ
description Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the intricate manner in which they interconnect with pyramidal cells (PCs). One prominent pathway is the frequency-dependent disynaptic inhibition (FDDI) formed between layer 5 PCs and mediated by Martinotti cells (MCs). Here, we show that simultaneous short bursts in four PCs are sufficient to exert FDDI in all neighboring PCs within the dimensions of a cortical column. This powerful inhibition is mediated by few interneurons, leading to strongly correlated membrane fluctuations and synchronous spiking between PCs simultaneously receiving FDDI. Somatic integration of such inhibition is independent and electrically isolated from monosynaptic excitation formed between the same PCs. FDDI is strongly shaped by I(h) in PC dendrites, which determines the effective integration time window for inhibitory and excitatory inputs. We propose a key disynaptic mechanism by which brief bursts generated by a few PCs can synchronize the activity in the pyramidal network.
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spelling doaj.art-398da57b31c3496c8b14e6fe046a0b9f2022-12-22T00:28:33ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852010-09-0189e100047310.1371/journal.pbio.1000473Brief bursts self-inhibit and correlate the pyramidal network. Thomas K BergerGilad SilberbergRodrigo PerinHenry MarkramInhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the intricate manner in which they interconnect with pyramidal cells (PCs). One prominent pathway is the frequency-dependent disynaptic inhibition (FDDI) formed between layer 5 PCs and mediated by Martinotti cells (MCs). Here, we show that simultaneous short bursts in four PCs are sufficient to exert FDDI in all neighboring PCs within the dimensions of a cortical column. This powerful inhibition is mediated by few interneurons, leading to strongly correlated membrane fluctuations and synchronous spiking between PCs simultaneously receiving FDDI. Somatic integration of such inhibition is independent and electrically isolated from monosynaptic excitation formed between the same PCs. FDDI is strongly shaped by I(h) in PC dendrites, which determines the effective integration time window for inhibitory and excitatory inputs. We propose a key disynaptic mechanism by which brief bursts generated by a few PCs can synchronize the activity in the pyramidal network.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20838653/pdf/?tool=EBI
spellingShingle Thomas K Berger
Gilad Silberberg
Rodrigo Perin
Henry Markram
Brief bursts self-inhibit and correlate the pyramidal network.
PLoS Biology
title Brief bursts self-inhibit and correlate the pyramidal network.
title_full Brief bursts self-inhibit and correlate the pyramidal network.
title_fullStr Brief bursts self-inhibit and correlate the pyramidal network.
title_full_unstemmed Brief bursts self-inhibit and correlate the pyramidal network.
title_short Brief bursts self-inhibit and correlate the pyramidal network.
title_sort brief bursts self inhibit and correlate the pyramidal network
url https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20838653/pdf/?tool=EBI
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