Nodding syndrome: A key role for sources of nutrition?
Nodding Syndrome (NS) has occurred among severely food-stressed communities in northern Uganda and several other East African populations that, with their forced physical displacement, have resorted to nutritional support from available wild plants and fungi, some of which have neurotoxic potential....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | eNeurologicalSci |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405650222000107 |
| _version_ | 1818555788903317504 |
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| author | P.S. Spencer C. Okot V.S. Palmer R. Valdes Angues R. Mazumder |
| author_facet | P.S. Spencer C. Okot V.S. Palmer R. Valdes Angues R. Mazumder |
| author_sort | P.S. Spencer |
| collection | DOAJ |
| description | Nodding Syndrome (NS) has occurred among severely food-stressed communities in northern Uganda and several other East African populations that, with their forced physical displacement, have resorted to nutritional support from available wild plants and fungi, some of which have neurotoxic potential. Among the latter is an agaric mushroom with an unknown content of hydrazine-generating agaritine, namely Agaricus bingensis, the unusually wide consumption of which may relate to the low serum levels of vitamin B6 in Ugandan NS subjects relative to controls. Hydrazine-related compounds induce patterns of DNA damage that promote neuropathological changes (tauopathy) reminiscent of those associated with established NS. While the cause of this childhood brain disease is unknown, we encourage increased attention to the role of malnutrition and B6 hypovitaminosis in the etiology of this devastating brain disease. |
| first_indexed | 2024-12-12T09:58:10Z |
| format | Article |
| id | doaj.art-398e13412d3f452dafc3bb898d5366e6 |
| institution | Directory Open Access Journal |
| issn | 2405-6502 |
| language | English |
| last_indexed | 2024-12-12T09:58:10Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | eNeurologicalSci |
| spelling | doaj.art-398e13412d3f452dafc3bb898d5366e62022-12-22T00:28:03ZengElseviereNeurologicalSci2405-65022022-06-0127100401Nodding syndrome: A key role for sources of nutrition?P.S. Spencer0C. Okot1V.S. Palmer2R. Valdes Angues3R. Mazumder4Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, USA; Corresponding author at: Oregon Health & Science University (Neurology), S.W. Sam Jackson Park Road, Portland, OR 97239, USA.Case-worker in Gulu, UgandaDepartment of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USADepartment of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USADepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, USANodding Syndrome (NS) has occurred among severely food-stressed communities in northern Uganda and several other East African populations that, with their forced physical displacement, have resorted to nutritional support from available wild plants and fungi, some of which have neurotoxic potential. Among the latter is an agaric mushroom with an unknown content of hydrazine-generating agaritine, namely Agaricus bingensis, the unusually wide consumption of which may relate to the low serum levels of vitamin B6 in Ugandan NS subjects relative to controls. Hydrazine-related compounds induce patterns of DNA damage that promote neuropathological changes (tauopathy) reminiscent of those associated with established NS. While the cause of this childhood brain disease is unknown, we encourage increased attention to the role of malnutrition and B6 hypovitaminosis in the etiology of this devastating brain disease.http://www.sciencedirect.com/science/article/pii/S2405650222000107DisplacementMalnutritionHypovitaminosisPyridoxineAgaritineTauopathy |
| spellingShingle | P.S. Spencer C. Okot V.S. Palmer R. Valdes Angues R. Mazumder Nodding syndrome: A key role for sources of nutrition? eNeurologicalSci Displacement Malnutrition Hypovitaminosis Pyridoxine Agaritine Tauopathy |
| title | Nodding syndrome: A key role for sources of nutrition? |
| title_full | Nodding syndrome: A key role for sources of nutrition? |
| title_fullStr | Nodding syndrome: A key role for sources of nutrition? |
| title_full_unstemmed | Nodding syndrome: A key role for sources of nutrition? |
| title_short | Nodding syndrome: A key role for sources of nutrition? |
| title_sort | nodding syndrome a key role for sources of nutrition |
| topic | Displacement Malnutrition Hypovitaminosis Pyridoxine Agaritine Tauopathy |
| url | http://www.sciencedirect.com/science/article/pii/S2405650222000107 |
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