Effect of cyclic substituents on the anti-cancer activity and DNA interaction of ruthenium(II) bis-phenanthroline dipyridoquinoline

Effect of cyclic substituents on the anti-cancer activity and DNA interaction of ruthenium(II) bis-phenanthroline dipyridoquinoline

Introduction: Ruthenium(II) complexes have emerged recently as candidates for anti-cancer therapy, where activity is related to lipohilicity, cellular localization, and specific interactions with biomolecules.Methods: In this work, two novel complexes were synthesized and are reported based on the [...

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Bibliographic Details
Main Authors: Etubonesi E. Nyong-Bassey, Andrew L. Hicks, Poppy Bergin, Eimer M. Tuite, Valery Kozhevnikov, Stephany Veuger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
AFM
viscometry
intercalation
cytotoxicity
lipophilicity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1252285/full

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