Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by abnormal alpha-synuclein aggregation and Lewy body formation, which leads to neurodegeneration and dopaminergic cell death. Currently there is no cure for PD. Thus, it is imperative to develop a new...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-06-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/25/9/10.2741/4874 |
| _version_ | 1818207231515033600 |
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| author | Chun Yang Yan Gao |
| author_facet | Chun Yang Yan Gao |
| author_sort | Chun Yang |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by abnormal alpha-synuclein aggregation and Lewy body formation, which leads to neurodegeneration and dopaminergic cell death. Currently there is no cure for PD. Thus, it is imperative to develop a new therapeutic approach. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a member of unconventional evolutionary conserved protein families. It has unique molecular structure and capable to detect and rescue apoptotic neurons. MANF protein could selectively enhance the survival and sprouting of nigral dopaminergic neurons in vitro. Studies have shown that MANF can protect and repair dopaminergic neurons in animal models of PD. MANF is localized in the endoplasmic reticulum (ER) lumen function in regulation of ER stress and unfolded protein responses. Its C terminal domain is complete homologous to SAP domain of Ku70, which functions in anti-apoptosis. In this review, we described molecular structure, tissue expression of MANF, and summarized preclinical studies using MANF for PD therapy. We also discussed the mechanisms of MANF for the treatment of PD. |
| first_indexed | 2024-12-12T04:25:38Z |
| format | Article |
| id | doaj.art-398e45e0383b480b9c0deba0579b9d58 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-12T04:25:38Z |
| publishDate | 2020-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-398e45e0383b480b9c0deba0579b9d582022-12-22T00:38:12ZengIMR PressFrontiers in Bioscience-Landmark2768-67012020-06-012591718173110.2741/4874S2768-6701(20)00148-3Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s diseaseChun Yang0Yan Gao1Department of Anatomy and Histology and Embryology, Capital Medical University, Beijing, ChinaDepartment of Anatomy and Histology and Embryology, Capital Medical University, Beijing, ChinaParkinson’s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by abnormal alpha-synuclein aggregation and Lewy body formation, which leads to neurodegeneration and dopaminergic cell death. Currently there is no cure for PD. Thus, it is imperative to develop a new therapeutic approach. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a member of unconventional evolutionary conserved protein families. It has unique molecular structure and capable to detect and rescue apoptotic neurons. MANF protein could selectively enhance the survival and sprouting of nigral dopaminergic neurons in vitro. Studies have shown that MANF can protect and repair dopaminergic neurons in animal models of PD. MANF is localized in the endoplasmic reticulum (ER) lumen function in regulation of ER stress and unfolded protein responses. Its C terminal domain is complete homologous to SAP domain of Ku70, which functions in anti-apoptosis. In this review, we described molecular structure, tissue expression of MANF, and summarized preclinical studies using MANF for PD therapy. We also discussed the mechanisms of MANF for the treatment of PD.https://www.imrpress.com/journal/FBL/25/9/10.2741/4874mesencephalic astrocyte-derived neurotrophic factordopaminergic neuronparkinson’s diseasereview |
| spellingShingle | Chun Yang Yan Gao Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease Frontiers in Bioscience-Landmark mesencephalic astrocyte-derived neurotrophic factor dopaminergic neuron parkinson’s disease review |
| title | Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease |
| title_full | Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease |
| title_fullStr | Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease |
| title_full_unstemmed | Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease |
| title_short | Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease |
| title_sort | mesencephalic astrocyte derived neurotrophic factor a treatment option for parkinson s disease |
| topic | mesencephalic astrocyte-derived neurotrophic factor dopaminergic neuron parkinson’s disease review |
| url | https://www.imrpress.com/journal/FBL/25/9/10.2741/4874 |
| work_keys_str_mv | AT chunyang mesencephalicastrocytederivedneurotrophicfactoratreatmentoptionforparkinsonsdisease AT yangao mesencephalicastrocytederivedneurotrophicfactoratreatmentoptionforparkinsonsdisease |