Trimethylamine-N-oxide aggravated the sympathetic excitation in D-galactose induced aging rats by down-regulating P2Y12 receptor in microglia

Trimethylamine-N-oxide aggravated the sympathetic excitation in D-galactose induced aging rats by down-regulating P2Y12 receptor in microglia

This study aimed to determine whether trimethylamine N-oxide (TMAO) was involved in sympathetic activation in aging and the underlying mechanisms. Our hypothesis is TMAO reduces P2Y12 receptor (P2Y12R) and induces microglia-mediated inflammation in the paraventricular nucleus (PVN), then leading to...

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Bibliographic Details
Main Authors: Ping Wang, Yuan Mi, Hao Yu, Xu Teng, Sheng Jin, Lin Xiao, Hongmei Xue, Danyang Tian, Qi Guo, Yuming Wu
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Aging
Trimethylamine N-oxide
Sympathetic excitation
Neuroinflammation
P2Y12R
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224004335

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http://www.sciencedirect.com/science/article/pii/S0753332224004335

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