Integrin α2β1-targeting ferritin nanocarrier traverses the blood–brain barrier for effective glioma chemotherapy
Abstract Background Ferritin, the natural iron storage protein complex, self-assembles into a uniform cage-like structure. Human H-ferritin (HFn) has been shown to transverse the blood–brain barrier (BBB) by binding to transferrin receptor 1 (TfR1), which is abundant in endothelial cells and overexp...
Main Authors: | Chiun-Wei Huang, Chia-Pao Chuang, Yan-Jun Chen, Hsu-Yuan Wang, Jia-Jia Lin, Chiung-Yin Huang, Kuo-Chen Wei, Feng-Ting Huang |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-06-01
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Series: | Journal of Nanobiotechnology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12951-021-00925-1 |
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