Proinflammatory Responses in SARS-CoV-2 and Soluble Spike Glycoprotein S1 Subunit Activated Human Macrophages

Proinflammatory Responses in SARS-CoV-2 and Soluble Spike Glycoprotein S1 Subunit Activated Human Macrophages

Critically ill COVID-19 patients display signs of generalized hyperinflammation. Macrophages trigger inflammation to eliminate pathogens and repair tissue, but this process can also lead to hyperinflammation and resulting exaggerated disease. The role of macrophages in dysregulated inflammation duri...

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Bibliographic Details
Main Authors: Kim Chiok, Kevin Hutchison, Lindsay Grace Miller, Santanu Bose, Tanya A. Miura
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
COVID-19
SARS-CoV-2
hyperinflammation
spike
S1 subunit
macrophages
Online Access:https://www.mdpi.com/1999-4915/15/3/754

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