Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn’t!
In a two-part article published in 2009, we discussed the limitations of conventional radiation therapy, the challenges of studying new technologies in radiation oncology, and summarized the state-of-the science for various malignancies (1, 2). Here, we summarize some of the most important prospecti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2018.00130/full |
| _version_ | 1818251800949555200 |
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| author | Kaveh Zakeri Kaveh Zakeri C. Norman Coleman Bhadrasain Vikram |
| author_facet | Kaveh Zakeri Kaveh Zakeri C. Norman Coleman Bhadrasain Vikram |
| author_sort | Kaveh Zakeri |
| collection | DOAJ |
| description | In a two-part article published in 2009, we discussed the limitations of conventional radiation therapy, the challenges of studying new technologies in radiation oncology, and summarized the state-of-the science for various malignancies (1, 2). Here, we summarize some of the most important prospective, randomized trials that during the intervening years have attempted to improve the tumor control and/or decrease the adverse effects of radiation therapy. For consistency, we have focused here on the null and alternate hypotheses as articulated by the investigators at the onset of each trial, since the outcome of the investigational treatment should be considered clinically significant only if the null hypothesis was rejected. The readers (and patients) are of course free to make their own judgments about the clinical significance of the results when the null hypothesis was not rejected. |
| first_indexed | 2024-12-12T16:14:03Z |
| format | Article |
| id | doaj.art-39917783ec414fbb84559282e66b3a5c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T16:14:03Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-39917783ec414fbb84559282e66b3a5c2022-12-22T00:19:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-04-01810.3389/fonc.2018.00130349405Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn’t!Kaveh Zakeri0Kaveh Zakeri1C. Norman Coleman2Bhadrasain Vikram3Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, United StatesDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, United StatesRadiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, United StatesRadiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, United StatesIn a two-part article published in 2009, we discussed the limitations of conventional radiation therapy, the challenges of studying new technologies in radiation oncology, and summarized the state-of-the science for various malignancies (1, 2). Here, we summarize some of the most important prospective, randomized trials that during the intervening years have attempted to improve the tumor control and/or decrease the adverse effects of radiation therapy. For consistency, we have focused here on the null and alternate hypotheses as articulated by the investigators at the onset of each trial, since the outcome of the investigational treatment should be considered clinically significant only if the null hypothesis was rejected. The readers (and patients) are of course free to make their own judgments about the clinical significance of the results when the null hypothesis was not rejected.http://journal.frontiersin.org/article/10.3389/fonc.2018.00130/fullrandomized trialsradiation oncologysurvivallocal controladverse events |
| spellingShingle | Kaveh Zakeri Kaveh Zakeri C. Norman Coleman Bhadrasain Vikram Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn’t! Frontiers in Oncology randomized trials radiation oncology survival local control adverse events |
| title | Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn’t! |
| title_full | Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn’t! |
| title_fullStr | Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn’t! |
| title_full_unstemmed | Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn’t! |
| title_short | Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn’t! |
| title_sort | radiation oncology in the 21st century prospective randomized trials that changed practice or didn t |
| topic | randomized trials radiation oncology survival local control adverse events |
| url | http://journal.frontiersin.org/article/10.3389/fonc.2018.00130/full |
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