NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes
Stress granules (SG) comprise aggregates of cellular messenger ribonucleoproteins (mRNPs) but how they form is unclear. Here, the authors identify NEDD4, an E3 ubiquitin ligase, as regulating the RNA binding protein NANOS2 and turnover of mRNP components, and so SG disassembly in spermatogonial stem...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15662 |
| _version_ | 1818423089493442560 |
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| author | Zhi Zhou Hiroshi Kawabe Atsushi Suzuki Kaori Shinmyozu Yumiko Saga |
| author_facet | Zhi Zhou Hiroshi Kawabe Atsushi Suzuki Kaori Shinmyozu Yumiko Saga |
| author_sort | Zhi Zhou |
| collection | DOAJ |
| description | Stress granules (SG) comprise aggregates of cellular messenger ribonucleoproteins (mRNPs) but how they form is unclear. Here, the authors identify NEDD4, an E3 ubiquitin ligase, as regulating the RNA binding protein NANOS2 and turnover of mRNP components, and so SG disassembly in spermatogonial stem cells. |
| first_indexed | 2024-12-14T13:36:36Z |
| format | Article |
| id | doaj.art-39954f4144a94d96ab7d987363f9af6f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:36:36Z |
| publishDate | 2017-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-39954f4144a94d96ab7d987363f9af6f2022-12-21T22:59:33ZengNature PortfolioNature Communications2041-17232017-06-018111310.1038/ncomms15662NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexesZhi Zhou0Hiroshi Kawabe1Atsushi Suzuki2Kaori Shinmyozu3Yumiko Saga4Division of Mammalian Development, Genetic Strains Research Center, National Institute of GeneticsDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineDivision of Materials Science and Chemical Engineering, Faculty of Engineering, Yokohama National UniversityNational Cerebral and Cardiovascular CenterDivision of Mammalian Development, Genetic Strains Research Center, National Institute of GeneticsStress granules (SG) comprise aggregates of cellular messenger ribonucleoproteins (mRNPs) but how they form is unclear. Here, the authors identify NEDD4, an E3 ubiquitin ligase, as regulating the RNA binding protein NANOS2 and turnover of mRNP components, and so SG disassembly in spermatogonial stem cells.https://doi.org/10.1038/ncomms15662 |
| spellingShingle | Zhi Zhou Hiroshi Kawabe Atsushi Suzuki Kaori Shinmyozu Yumiko Saga NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes Nature Communications |
| title | NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes |
| title_full | NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes |
| title_fullStr | NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes |
| title_full_unstemmed | NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes |
| title_short | NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes |
| title_sort | nedd4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes |
| url | https://doi.org/10.1038/ncomms15662 |
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