Quantitative Evaluation of Fundus Autofluorescence in Laser Photocoagulation Scars for Diabetic Retinopathy: Conventional vs. Short-Pulse Laser
Short-pulse laser is popular for its advantages like less pain. However, its effectiveness is still debated. The aim of this study was to compare fundus autofluorescence (FAF) luminosity changes of laser photocoagulation scars between the conventional laser (0.2 s) and the short-pulse laser (0.02 s)...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/9/1901 |
| _version_ | 1797579152727998464 |
|---|---|
| author | Toshiya Kimura Shuntaro Ogura Tsutomu Yasukawa Miho Nozaki |
| author_facet | Toshiya Kimura Shuntaro Ogura Tsutomu Yasukawa Miho Nozaki |
| author_sort | Toshiya Kimura |
| collection | DOAJ |
| description | Short-pulse laser is popular for its advantages like less pain. However, its effectiveness is still debated. The aim of this study was to compare fundus autofluorescence (FAF) luminosity changes of laser photocoagulation scars between the conventional laser (0.2 s) and the short-pulse laser (0.02 s) for diabetic retinopathy. Conventional and short-pulse laser photocoagulations were performed in six and seven eyes, respectively. FAF images were captured at 1, 3, 6, 12, and 18 months after the treatments. To evaluate FAF, individual gray-scale values of the laser scars adjacent to the retinal arcade vessels were recorded; then, the mean gray values of the scars were divided by the luminosity of arcade vein. The average luminosity ratio of laser scars at 1, 3, 6, 12, and 18 months were 1.51 ± 0.17, 1.26 ± 0.07, 1.21 ± 0.03, 0.95 ± 0.11, and 0.89 ± 0.05 with conventional laser and 1.91 ± 0.13, 1.50 ± 0.15, 1.26 ± 0.08, 1.18 ± 0.06, and 0.97 ± 0.04 with short-pulse laser, respectively. Findings suggest the short-pulse laser displayed delayed hypoautofluorescence progression. This implies potential postponement in post-irradiation atrophic changes, as well as metabolic amelioration delay in the ischemic retina, when compared to conventional laser treatment. |
| first_indexed | 2024-03-10T22:31:51Z |
| format | Article |
| id | doaj.art-3995819ab1ad48419f96435c5b720391 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T22:31:51Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-3995819ab1ad48419f96435c5b7203912023-11-19T11:37:52ZengMDPI AGLife2075-17292023-09-01139190110.3390/life13091901Quantitative Evaluation of Fundus Autofluorescence in Laser Photocoagulation Scars for Diabetic Retinopathy: Conventional vs. Short-Pulse LaserToshiya Kimura0Shuntaro Ogura1Tsutomu Yasukawa2Miho Nozaki3Department of Ophthalmology, Laser Eye Center, Nagoya City University East Medical Center, Nagoya 464-8547, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Ophthalmology, Laser Eye Center, Nagoya City University East Medical Center, Nagoya 464-8547, JapanShort-pulse laser is popular for its advantages like less pain. However, its effectiveness is still debated. The aim of this study was to compare fundus autofluorescence (FAF) luminosity changes of laser photocoagulation scars between the conventional laser (0.2 s) and the short-pulse laser (0.02 s) for diabetic retinopathy. Conventional and short-pulse laser photocoagulations were performed in six and seven eyes, respectively. FAF images were captured at 1, 3, 6, 12, and 18 months after the treatments. To evaluate FAF, individual gray-scale values of the laser scars adjacent to the retinal arcade vessels were recorded; then, the mean gray values of the scars were divided by the luminosity of arcade vein. The average luminosity ratio of laser scars at 1, 3, 6, 12, and 18 months were 1.51 ± 0.17, 1.26 ± 0.07, 1.21 ± 0.03, 0.95 ± 0.11, and 0.89 ± 0.05 with conventional laser and 1.91 ± 0.13, 1.50 ± 0.15, 1.26 ± 0.08, 1.18 ± 0.06, and 0.97 ± 0.04 with short-pulse laser, respectively. Findings suggest the short-pulse laser displayed delayed hypoautofluorescence progression. This implies potential postponement in post-irradiation atrophic changes, as well as metabolic amelioration delay in the ischemic retina, when compared to conventional laser treatment.https://www.mdpi.com/2075-1729/13/9/1901diabetic retinopathypanretinal photocoagulationconventional lasershort-pulse laserfundus autofluorescencehypoautofluorescence |
| spellingShingle | Toshiya Kimura Shuntaro Ogura Tsutomu Yasukawa Miho Nozaki Quantitative Evaluation of Fundus Autofluorescence in Laser Photocoagulation Scars for Diabetic Retinopathy: Conventional vs. Short-Pulse Laser Life diabetic retinopathy panretinal photocoagulation conventional laser short-pulse laser fundus autofluorescence hypoautofluorescence |
| title | Quantitative Evaluation of Fundus Autofluorescence in Laser Photocoagulation Scars for Diabetic Retinopathy: Conventional vs. Short-Pulse Laser |
| title_full | Quantitative Evaluation of Fundus Autofluorescence in Laser Photocoagulation Scars for Diabetic Retinopathy: Conventional vs. Short-Pulse Laser |
| title_fullStr | Quantitative Evaluation of Fundus Autofluorescence in Laser Photocoagulation Scars for Diabetic Retinopathy: Conventional vs. Short-Pulse Laser |
| title_full_unstemmed | Quantitative Evaluation of Fundus Autofluorescence in Laser Photocoagulation Scars for Diabetic Retinopathy: Conventional vs. Short-Pulse Laser |
| title_short | Quantitative Evaluation of Fundus Autofluorescence in Laser Photocoagulation Scars for Diabetic Retinopathy: Conventional vs. Short-Pulse Laser |
| title_sort | quantitative evaluation of fundus autofluorescence in laser photocoagulation scars for diabetic retinopathy conventional vs short pulse laser |
| topic | diabetic retinopathy panretinal photocoagulation conventional laser short-pulse laser fundus autofluorescence hypoautofluorescence |
| url | https://www.mdpi.com/2075-1729/13/9/1901 |
| work_keys_str_mv | AT toshiyakimura quantitativeevaluationoffundusautofluorescenceinlaserphotocoagulationscarsfordiabeticretinopathyconventionalvsshortpulselaser AT shuntaroogura quantitativeevaluationoffundusautofluorescenceinlaserphotocoagulationscarsfordiabeticretinopathyconventionalvsshortpulselaser AT tsutomuyasukawa quantitativeevaluationoffundusautofluorescenceinlaserphotocoagulationscarsfordiabeticretinopathyconventionalvsshortpulselaser AT mihonozaki quantitativeevaluationoffundusautofluorescenceinlaserphotocoagulationscarsfordiabeticretinopathyconventionalvsshortpulselaser |