Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammography
Abstract Background To determine the proportion of “true” interval cancers and tumor characteristics of interval breast cancers prior to, during and after the transition from screen-film mammography screening (SFM) to full-field digital mammography screening (FFDM). Methods We included all women wit...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3294-5 |
| _version_ | 1811303551220056064 |
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| author | Rob M. G. van Bommel Roy Weber Adri C. Voogd Joost Nederend Marieke W. J. Louwman Dick Venderink Luc J. A. Strobbe Matthieu J. C. Rutten Menno L. Plaisier Paul N. Lohle Marianne J. H. Hooijen Vivianne C.G. Tjan-Heijnen Lucien E. M. Duijm |
| author_facet | Rob M. G. van Bommel Roy Weber Adri C. Voogd Joost Nederend Marieke W. J. Louwman Dick Venderink Luc J. A. Strobbe Matthieu J. C. Rutten Menno L. Plaisier Paul N. Lohle Marianne J. H. Hooijen Vivianne C.G. Tjan-Heijnen Lucien E. M. Duijm |
| author_sort | Rob M. G. van Bommel |
| collection | DOAJ |
| description | Abstract Background To determine the proportion of “true” interval cancers and tumor characteristics of interval breast cancers prior to, during and after the transition from screen-film mammography screening (SFM) to full-field digital mammography screening (FFDM). Methods We included all women with interval cancers detected between January 2006 and January 2014. Breast imaging reports, biopsy results and breast surgery reports of all women recalled at screening mammography and of all women with interval breast cancers were collected. Two experienced screening radiologists reviewed the diagnostic mammograms, on which the interval cancers were diagnosed, as well as the prior screening mammograms and determined whether or not the interval cancer had been missed on the most recent screening mammogram. If not missed, the cancer was considered an occult (“true”) interval cancer. Results A total of 442 interval cancers had been diagnosed, of which 144 at SFM with a prior SFM (SFM-SFM), 159 at FFDM with a prior SFM (FFDM-SFM) and 139 at FFDM with a prior FFDM (FFDM-FFDM). The transition from SFM to FFDM screening resulted in the diagnosis of more occult (“true”) interval cancers at FFDM-SFM than at SFM-SFM (65.4% (104/159) versus 49.3% (71/144), P < 0.01), but this increase was no longer statistically significant in women who had been screened digitally for the second time (57.6% (80/139) at FFDM-FFDM versus 49.3% (71/144) at SFM-SFM). Tumor characteristics were comparable for the three interval cancer cohorts, except of a lower porportion (75.7 and 78.0% versus 67.2% af FFDM-FFDM, P < 0.05) of invasive ductal cancers at FFDM with prior FFDM. Conclusions An increase in the proportion of occult interval cancers is observed during the transition from SFM to FFDM screening mammography. However, this increase seems temporary and is no longer detectable after the second round of digital screening. Tumor characteristics and type of surgery are comparable for interval cancers detected prior to, during and after the transition from SFM to FFDM screening mammography, except of a lower proportion of invasive ductal cancers after the transition. |
| first_indexed | 2024-04-13T07:48:50Z |
| format | Article |
| id | doaj.art-3997255a6c51455fb91675b8ac065d3d |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T07:48:50Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-3997255a6c51455fb91675b8ac065d3d2022-12-22T02:55:35ZengBMCBMC Cancer1471-24072017-05-011711710.1186/s12885-017-3294-5Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammographyRob M. G. van Bommel0Roy Weber1Adri C. Voogd2Joost Nederend3Marieke W. J. Louwman4Dick Venderink5Luc J. A. Strobbe6Matthieu J. C. Rutten7Menno L. Plaisier8Paul N. Lohle9Marianne J. H. Hooijen10Vivianne C.G. Tjan-Heijnen11Lucien E. M. Duijm12Department of Radiology, Catharina HospitalDepartment of Radiology, Catharina HospitalDepartment of Epidemiology, Maastricht UniversityDepartment of Radiology, Catharina HospitalDepartment of Research, Netherlands Comprehensive Cancer Organization (IKNL)Department of Radiology, Canisius Wilhelmina HospitalDepartment of Surgery, Canisius-Wilhelmina HospitalDepartment of Radiology, Jeroen Bosch HospitalDepartment of Radiology, Maxima Medical CentreDepartment of Radiology, St Elisabeth HospitalDepartment of Radiology, St Anna HospitalDepartment of Internal Medicine, Division of Medical Oncology, GROW, Maastricht University Medical CentreDepartment of Radiology, Canisius Wilhelmina HospitalAbstract Background To determine the proportion of “true” interval cancers and tumor characteristics of interval breast cancers prior to, during and after the transition from screen-film mammography screening (SFM) to full-field digital mammography screening (FFDM). Methods We included all women with interval cancers detected between January 2006 and January 2014. Breast imaging reports, biopsy results and breast surgery reports of all women recalled at screening mammography and of all women with interval breast cancers were collected. Two experienced screening radiologists reviewed the diagnostic mammograms, on which the interval cancers were diagnosed, as well as the prior screening mammograms and determined whether or not the interval cancer had been missed on the most recent screening mammogram. If not missed, the cancer was considered an occult (“true”) interval cancer. Results A total of 442 interval cancers had been diagnosed, of which 144 at SFM with a prior SFM (SFM-SFM), 159 at FFDM with a prior SFM (FFDM-SFM) and 139 at FFDM with a prior FFDM (FFDM-FFDM). The transition from SFM to FFDM screening resulted in the diagnosis of more occult (“true”) interval cancers at FFDM-SFM than at SFM-SFM (65.4% (104/159) versus 49.3% (71/144), P < 0.01), but this increase was no longer statistically significant in women who had been screened digitally for the second time (57.6% (80/139) at FFDM-FFDM versus 49.3% (71/144) at SFM-SFM). Tumor characteristics were comparable for the three interval cancer cohorts, except of a lower porportion (75.7 and 78.0% versus 67.2% af FFDM-FFDM, P < 0.05) of invasive ductal cancers at FFDM with prior FFDM. Conclusions An increase in the proportion of occult interval cancers is observed during the transition from SFM to FFDM screening mammography. However, this increase seems temporary and is no longer detectable after the second round of digital screening. Tumor characteristics and type of surgery are comparable for interval cancers detected prior to, during and after the transition from SFM to FFDM screening mammography, except of a lower proportion of invasive ductal cancers after the transition.http://link.springer.com/article/10.1186/s12885-017-3294-5Breast cancerMass screeningMammographyReferral and consultationEarly detection of cancer |
| spellingShingle | Rob M. G. van Bommel Roy Weber Adri C. Voogd Joost Nederend Marieke W. J. Louwman Dick Venderink Luc J. A. Strobbe Matthieu J. C. Rutten Menno L. Plaisier Paul N. Lohle Marianne J. H. Hooijen Vivianne C.G. Tjan-Heijnen Lucien E. M. Duijm Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammography BMC Cancer Breast cancer Mass screening Mammography Referral and consultation Early detection of cancer |
| title | Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammography |
| title_full | Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammography |
| title_fullStr | Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammography |
| title_full_unstemmed | Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammography |
| title_short | Interval breast cancer characteristics before, during and after the transition from screen-film to full-field digital screening mammography |
| title_sort | interval breast cancer characteristics before during and after the transition from screen film to full field digital screening mammography |
| topic | Breast cancer Mass screening Mammography Referral and consultation Early detection of cancer |
| url | http://link.springer.com/article/10.1186/s12885-017-3294-5 |
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