Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment
Stroke often leads to persistent post-stroke cognitive impairment (PSCI), which mainly manifests as impairment in learning and memory. The pathogenesis remains unclear as present, but it is closely related to mitochondrial dysfunction, and healthy mitochondria are essential for neuronal survival. Re...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2023-10-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/1688453761405-1834539413.pdf |
| _version_ | 1797216554090233856 |
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| author | XIAO Yuqian, BAI Yanjie, WANG Yan, CHEN Shuying, CHEN Limin, SUN Kexin, WAN Jun |
| author_facet | XIAO Yuqian, BAI Yanjie, WANG Yan, CHEN Shuying, CHEN Limin, SUN Kexin, WAN Jun |
| author_sort | XIAO Yuqian, BAI Yanjie, WANG Yan, CHEN Shuying, CHEN Limin, SUN Kexin, WAN Jun |
| collection | DOAJ |
| description | Stroke often leads to persistent post-stroke cognitive impairment (PSCI), which mainly manifests as impairment in learning and memory. The pathogenesis remains unclear as present, but it is closely related to mitochondrial dysfunction, and healthy mitochondria are essential for neuronal survival. Recent studies have shown that intercellular mitochondrial transfer can be linked to stroke through increasing neuronal viability, enhancing mitochondrial metabolism, and modulating neuroinflammation, thereby improving cognitive impairment. This review overviews the mechanisms of mitochondrial transfer and the key role of intercellular mitochondrial transfer in PSCI, and discusses that mitochondrial transplantation may serve as a novel therapeutic intervention for PSCI, providing references for its clinical management. |
| first_indexed | 2024-04-24T11:47:48Z |
| format | Article |
| id | doaj.art-399779e2d590487f9f492f19169f6aff |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:47:48Z |
| publishDate | 2023-10-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-399779e2d590487f9f492f19169f6aff2024-04-09T08:44:32ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722023-10-0126303833384010.12114/j.issn.1007-9572.2023.0162Research Progress of Mitochondrial Transfer in Post-stroke Cognitive ImpairmentXIAO Yuqian, BAI Yanjie, WANG Yan, CHEN Shuying, CHEN Limin, SUN Kexin, WAN Jun01. Henan University of Chinese Medicine, Zhengzhou 450046, China;2. The First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, ChinaStroke often leads to persistent post-stroke cognitive impairment (PSCI), which mainly manifests as impairment in learning and memory. The pathogenesis remains unclear as present, but it is closely related to mitochondrial dysfunction, and healthy mitochondria are essential for neuronal survival. Recent studies have shown that intercellular mitochondrial transfer can be linked to stroke through increasing neuronal viability, enhancing mitochondrial metabolism, and modulating neuroinflammation, thereby improving cognitive impairment. This review overviews the mechanisms of mitochondrial transfer and the key role of intercellular mitochondrial transfer in PSCI, and discusses that mitochondrial transplantation may serve as a novel therapeutic intervention for PSCI, providing references for its clinical management.https://www.chinagp.net/fileup/1007-9572/PDF/1688453761405-1834539413.pdfstroke|cognition disorders|mitochondrial transfer|tunneling nanotubes|extracellular vesicles|gap junction|review |
| spellingShingle | XIAO Yuqian, BAI Yanjie, WANG Yan, CHEN Shuying, CHEN Limin, SUN Kexin, WAN Jun Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment Zhongguo quanke yixue stroke|cognition disorders|mitochondrial transfer|tunneling nanotubes|extracellular vesicles|gap junction|review |
| title | Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment |
| title_full | Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment |
| title_fullStr | Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment |
| title_full_unstemmed | Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment |
| title_short | Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment |
| title_sort | research progress of mitochondrial transfer in post stroke cognitive impairment |
| topic | stroke|cognition disorders|mitochondrial transfer|tunneling nanotubes|extracellular vesicles|gap junction|review |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/1688453761405-1834539413.pdf |
| work_keys_str_mv | AT xiaoyuqianbaiyanjiewangyanchenshuyingchenliminsunkexinwanjun researchprogressofmitochondrialtransferinpoststrokecognitiveimpairment |