High throughput techniques for discovering new glycine receptor modulators and their binding sites

High throughput techniques for discovering new glycine receptor modulators and their binding sites

The inhibitory glycine receptor (GlyR) is a member of the Cys-loop receptor family that mediates inhibitory neurotransmission in the central nervous system. These receptors are emerging as potential drug targets for inflammatory pain, immunomodulation, spasticity and epilepsy. Antagonists that speci...

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Bibliographic Details
Main Authors: Daniel F Gilbert, Robiul Islam, Timothy P Lynagh, Joe Lynch, Timothy I Webb
Format: Article
Language:English
Published: Frontiers Media S.A. 2009-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Drug Discovery
Pain
Pharmacology
Cys-loop receptor
chloride channel
high throughput
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.02.017.2009/full

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