Systematic Influence of Circulating Bilirubin Levels on Osteoporosis
Observational studies report some association between circulating bilirubin levels and osteoporosis, but it is unknown if this association is causal or confounded. In this two-sample Mendelian randomization (MR) study, we included a large genome-wide association study (GWAS) associated with total bi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.719920/full |
| _version_ | 1824043731199721472 |
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| author | Jinqiu Zhao Muzi Zhang Zhengxue Quan Liang Deng Yongguo Li Bin He |
| author_facet | Jinqiu Zhao Muzi Zhang Zhengxue Quan Liang Deng Yongguo Li Bin He |
| author_sort | Jinqiu Zhao |
| collection | DOAJ |
| description | Observational studies report some association between circulating bilirubin levels and osteoporosis, but it is unknown if this association is causal or confounded. In this two-sample Mendelian randomization (MR) study, we included a large genome-wide association study (GWAS) associated with total bilirubin levels among 317,639 people, a large meta-analysis to identify genetic variants associated with bone mineral density (BMD) estimated by heel quantitative ultrasound (eBMD) among 426,824 individuals and fracture among 1.2 million individuals. The results revealed that circulating bilirubin levels had no causal influence on eBMD (beta-estimate: 0.004, 95% confidence interval [CI]: -0.019 to 0.028, SE:0.012, P-value=0.705) or the risk of fracture (beta-estimate: -0.009, 95% CI: -0.035 to 0.017, SE:0.013, P-value=0.488), which were both confirmed by multiple sensitivity analyses. Our results confirm that circulating bilirubin levels have no causal role in eBMD or the incidence of fracture, indicating that circulating bilirubin levels is unlikely to be a causal risk factor for osteoporosis or fracture. |
| first_indexed | 2024-12-22T23:59:55Z |
| format | Article |
| id | doaj.art-399975cfb73e42739a6989ea0b7d306d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-22T23:59:55Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-399975cfb73e42739a6989ea0b7d306d2022-12-21T18:07:50ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-08-011210.3389/fendo.2021.719920719920Systematic Influence of Circulating Bilirubin Levels on OsteoporosisJinqiu Zhao0Muzi Zhang1Zhengxue Quan2Liang Deng3Yongguo Li4Bin He5Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaObservational studies report some association between circulating bilirubin levels and osteoporosis, but it is unknown if this association is causal or confounded. In this two-sample Mendelian randomization (MR) study, we included a large genome-wide association study (GWAS) associated with total bilirubin levels among 317,639 people, a large meta-analysis to identify genetic variants associated with bone mineral density (BMD) estimated by heel quantitative ultrasound (eBMD) among 426,824 individuals and fracture among 1.2 million individuals. The results revealed that circulating bilirubin levels had no causal influence on eBMD (beta-estimate: 0.004, 95% confidence interval [CI]: -0.019 to 0.028, SE:0.012, P-value=0.705) or the risk of fracture (beta-estimate: -0.009, 95% CI: -0.035 to 0.017, SE:0.013, P-value=0.488), which were both confirmed by multiple sensitivity analyses. Our results confirm that circulating bilirubin levels have no causal role in eBMD or the incidence of fracture, indicating that circulating bilirubin levels is unlikely to be a causal risk factor for osteoporosis or fracture.https://www.frontiersin.org/articles/10.3389/fendo.2021.719920/fullosteoporosiscirculating bilirubin levelsBMDfractureMendelian randomization study |
| spellingShingle | Jinqiu Zhao Muzi Zhang Zhengxue Quan Liang Deng Yongguo Li Bin He Systematic Influence of Circulating Bilirubin Levels on Osteoporosis Frontiers in Endocrinology osteoporosis circulating bilirubin levels BMD fracture Mendelian randomization study |
| title | Systematic Influence of Circulating Bilirubin Levels on Osteoporosis |
| title_full | Systematic Influence of Circulating Bilirubin Levels on Osteoporosis |
| title_fullStr | Systematic Influence of Circulating Bilirubin Levels on Osteoporosis |
| title_full_unstemmed | Systematic Influence of Circulating Bilirubin Levels on Osteoporosis |
| title_short | Systematic Influence of Circulating Bilirubin Levels on Osteoporosis |
| title_sort | systematic influence of circulating bilirubin levels on osteoporosis |
| topic | osteoporosis circulating bilirubin levels BMD fracture Mendelian randomization study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.719920/full |
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