Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infection
Chronic hepatitis B (CHB) is an infectious disease caused by persistent infection with the hepatitis B virus (HBV) and is highly prevalent worldwide. Non-alcoholic fatty liver disease (NAFLD) is a group of liver diseases related to metabolic abnormalities, excluding those caused by alcohol consumpti...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2023-12-01
|
| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-12-1585.shtml |
| _version_ | 1797303986005475328 |
|---|---|
| author | BENEDICK Jun Er Chin SON Peng ZHANG Yifan WANG Junqing GUO Simin |
| author_facet | BENEDICK Jun Er Chin SON Peng ZHANG Yifan WANG Junqing GUO Simin |
| author_sort | BENEDICK Jun Er Chin |
| collection | DOAJ |
| description | Chronic hepatitis B (CHB) is an infectious disease caused by persistent infection with the hepatitis B virus (HBV) and is highly prevalent worldwide. Non-alcoholic fatty liver disease (NAFLD) is a group of liver diseases related to metabolic abnormalities, excluding those caused by alcohol consumption or other liver injury factors. In recent years, with improvement of living standards and changes in lifestyle, the incidence of NAFLD has been increasing substantially, becoming the most common type of liver diseases in China and Western countries, and the second leading cause of liver transplantation in the West. The rising prevalence of NAFLD has also led to an increase in the incidence of NAFLD in patients with chronic HBV infection. However, there is considerable controversy both domestically and internationally regarding the relationship between these two diseases, including the disease progression, pathogenesis, impact on antiviral treatment efficacy, and prognosis of these concomitant CHB and NAFLD patients. Currently, both domestic and international guidelines lack detailed descriptions of diagnostic and treatment strategies for these conditions. This article summarizes the recent research progress in concomitant CHB and NAFLD, including epidemiology, diagnostic criteria, the impact of NAFLD on the virology of HBV infection, potential mechanisms of NAFLD-induced negative regulation of HBV, the effect of NAFLD on antiviral therapy efficacy, and prognosis. This article aims to gain a deeper understanding of the diseases themselves and provide new insights for basic and clinical research as well as diagnostic and treatment approaches. |
| first_indexed | 2024-03-08T00:01:42Z |
| format | Article |
| id | doaj.art-3999787c5a2842e69ec7a5fe5450127a |
| institution | Directory Open Access Journal |
| issn | 1674-8115 |
| language | zho |
| last_indexed | 2024-03-08T00:01:42Z |
| publishDate | 2023-12-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj.art-3999787c5a2842e69ec7a5fe5450127a2024-02-18T02:27:34ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152023-12-0143121585159010.3969/j.issn.1674-8115.2023.12.0151674-8115（2023）12-1585-06Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infectionBENEDICK Jun Er Chin0SON Peng1ZHANG Yifan2WANG Junqing3GUO Simin4Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaShanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Hepatobiliary Surgery, Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, ChinaDepartment of Hepatobiliary Surgery, Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, ChinaInfectious Department, Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, ChinaChronic hepatitis B (CHB) is an infectious disease caused by persistent infection with the hepatitis B virus (HBV) and is highly prevalent worldwide. Non-alcoholic fatty liver disease (NAFLD) is a group of liver diseases related to metabolic abnormalities, excluding those caused by alcohol consumption or other liver injury factors. In recent years, with improvement of living standards and changes in lifestyle, the incidence of NAFLD has been increasing substantially, becoming the most common type of liver diseases in China and Western countries, and the second leading cause of liver transplantation in the West. The rising prevalence of NAFLD has also led to an increase in the incidence of NAFLD in patients with chronic HBV infection. However, there is considerable controversy both domestically and internationally regarding the relationship between these two diseases, including the disease progression, pathogenesis, impact on antiviral treatment efficacy, and prognosis of these concomitant CHB and NAFLD patients. Currently, both domestic and international guidelines lack detailed descriptions of diagnostic and treatment strategies for these conditions. This article summarizes the recent research progress in concomitant CHB and NAFLD, including epidemiology, diagnostic criteria, the impact of NAFLD on the virology of HBV infection, potential mechanisms of NAFLD-induced negative regulation of HBV, the effect of NAFLD on antiviral therapy efficacy, and prognosis. This article aims to gain a deeper understanding of the diseases themselves and provide new insights for basic and clinical research as well as diagnostic and treatment approaches.https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-12-1585.shtmlhepatitis b virus (hbv)chronic hepatitis b (chb)non-alcoholic fatty liver disease (nafld)antiviral therapyhepatocellular carcinoma |
| spellingShingle | BENEDICK Jun Er Chin SON Peng ZHANG Yifan WANG Junqing GUO Simin Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infection Shanghai Jiaotong Daxue xuebao. Yixue ban hepatitis b virus (hbv) chronic hepatitis b (chb) non-alcoholic fatty liver disease (nafld) antiviral therapy hepatocellular carcinoma |
| title | Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infection |
| title_full | Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infection |
| title_fullStr | Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infection |
| title_full_unstemmed | Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infection |
| title_short | Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infection |
| title_sort | research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis b infection |
| topic | hepatitis b virus (hbv) chronic hepatitis b (chb) non-alcoholic fatty liver disease (nafld) antiviral therapy hepatocellular carcinoma |
| url | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-12-1585.shtml |
| work_keys_str_mv | AT benedickjunerchin researchprogressoftheimpactofnonalcoholicfattyliverdiseaseonchronichepatitisbinfection AT sonpeng researchprogressoftheimpactofnonalcoholicfattyliverdiseaseonchronichepatitisbinfection AT zhangyifan researchprogressoftheimpactofnonalcoholicfattyliverdiseaseonchronichepatitisbinfection AT wangjunqing researchprogressoftheimpactofnonalcoholicfattyliverdiseaseonchronichepatitisbinfection AT guosimin researchprogressoftheimpactofnonalcoholicfattyliverdiseaseonchronichepatitisbinfection |