Explicit Gaussian Variational Approximation for the Poisson Lognormal Mixed Model

In recent years, the Poisson lognormal mixed model has been frequently used in modeling count data because it can accommodate both the over-dispersion of the data and the existence of within-subject correlation. Since the likelihood function of this model is expressed in terms of an intractable inte...

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Main Authors: Xiaoping Shi, Xiang-Sheng Wang, Augustine Wong
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Mathematics
Subjects:
Online Access:https://www.mdpi.com/2227-7390/10/23/4542
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author Xiaoping Shi
Xiang-Sheng Wang
Augustine Wong
author_facet Xiaoping Shi
Xiang-Sheng Wang
Augustine Wong
author_sort Xiaoping Shi
collection DOAJ
description In recent years, the Poisson lognormal mixed model has been frequently used in modeling count data because it can accommodate both the over-dispersion of the data and the existence of within-subject correlation. Since the likelihood function of this model is expressed in terms of an intractable integral, estimating the parameters and obtaining inference for the parameters are challenging problems. Some approximation procedures have been proposed in the literature; however, they are computationally intensive. Moreover, the existing studies of approximate parameter inference using the Gaussian variational approximation method are usually restricted to models with only one predictor. In this paper, we consider the Poisson lognormal mixed model with more than one predictor. By extending the Gaussian variational approximation method, we derive explicit forms for the estimators of the parameters and examine their properties, including the asymptotic distributions of the estimators of the parameters. Accurate inference for the parameters is also obtained. A real-life example demonstrates the applicability of the proposed method, and simulation studies illustrate the accuracy of the proposed method.
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spelling doaj.art-399bca9f0f964f119f9e681cc7f489422023-11-24T11:35:17ZengMDPI AGMathematics2227-73902022-12-011023454210.3390/math10234542Explicit Gaussian Variational Approximation for the Poisson Lognormal Mixed ModelXiaoping Shi0Xiang-Sheng Wang1Augustine Wong2Department of Computer Science, Mathematics, Physics and Statistics, University of British Columbia, Kelowna, BC V1V 1V7, CanadaDepartment of Mathematics, University of Louisiana at Lafayette, Lafayette, LA 70503, USADepartment of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, CanadaIn recent years, the Poisson lognormal mixed model has been frequently used in modeling count data because it can accommodate both the over-dispersion of the data and the existence of within-subject correlation. Since the likelihood function of this model is expressed in terms of an intractable integral, estimating the parameters and obtaining inference for the parameters are challenging problems. Some approximation procedures have been proposed in the literature; however, they are computationally intensive. Moreover, the existing studies of approximate parameter inference using the Gaussian variational approximation method are usually restricted to models with only one predictor. In this paper, we consider the Poisson lognormal mixed model with more than one predictor. By extending the Gaussian variational approximation method, we derive explicit forms for the estimators of the parameters and examine their properties, including the asymptotic distributions of the estimators of the parameters. Accurate inference for the parameters is also obtained. A real-life example demonstrates the applicability of the proposed method, and simulation studies illustrate the accuracy of the proposed method.https://www.mdpi.com/2227-7390/10/23/4542Gaussian variational approximationPoisson lognormal mixed modelexponential family modelmaximum likelihood estimationasymptotic distributionKullback–Leibler divergence
spellingShingle Xiaoping Shi
Xiang-Sheng Wang
Augustine Wong
Explicit Gaussian Variational Approximation for the Poisson Lognormal Mixed Model
Mathematics
Gaussian variational approximation
Poisson lognormal mixed model
exponential family model
maximum likelihood estimation
asymptotic distribution
Kullback–Leibler divergence
title Explicit Gaussian Variational Approximation for the Poisson Lognormal Mixed Model
title_full Explicit Gaussian Variational Approximation for the Poisson Lognormal Mixed Model
title_fullStr Explicit Gaussian Variational Approximation for the Poisson Lognormal Mixed Model
title_full_unstemmed Explicit Gaussian Variational Approximation for the Poisson Lognormal Mixed Model
title_short Explicit Gaussian Variational Approximation for the Poisson Lognormal Mixed Model
title_sort explicit gaussian variational approximation for the poisson lognormal mixed model
topic Gaussian variational approximation
Poisson lognormal mixed model
exponential family model
maximum likelihood estimation
asymptotic distribution
Kullback–Leibler divergence
url https://www.mdpi.com/2227-7390/10/23/4542
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