Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats
Objective: To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in rats. Methods: Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 days. Hematological, biochemical, electrocardiography, echocardiography, and hist...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=4;spage=156;epage=164;aulast=Khuntia |
| _version_ | 1797824430024425472 |
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| author | Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra Subash Chandra Parija |
| author_facet | Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra Subash Chandra Parija |
| author_sort | Gayatri Khuntia |
| collection | DOAJ |
| description | Objective: To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in rats.
Methods: Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 days. Hematological, biochemical, electrocardiography, echocardiography, and histopathological examinations were performed.
Results: Hesperidin decreased the neutrophil-to-lymphocyte ratio, calcium, creatine kinase-myoglobin binding, lactate dehydrogenase, IL-6, and lipid peroxidation, as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated rats. Moreover, it reduced peak systolic velocity and end-diastolic velocity while increasing heart rate. Arsenic trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin treatment.
Conclusions: Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats. Therefore, it can be further explored as a cardioprotective agent. |
| first_indexed | 2024-03-13T10:38:51Z |
| format | Article |
| id | doaj.art-399bd911860a4fc689f6d3a436b38f5b |
| institution | Directory Open Access Journal |
| issn | 2221-1691 2588-9222 |
| language | English |
| last_indexed | 2024-03-13T10:38:51Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-399bd911860a4fc689f6d3a436b38f5b2023-05-18T05:00:16ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912588-92222023-01-0113415616410.4103/2221-1691.374232Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in ratsGayatri KhuntiaJeevan Ranjan DashBiswadeep JenaUma Kanta MishraSubash Chandra ParijaObjective: To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in rats. Methods: Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 days. Hematological, biochemical, electrocardiography, echocardiography, and histopathological examinations were performed. Results: Hesperidin decreased the neutrophil-to-lymphocyte ratio, calcium, creatine kinase-myoglobin binding, lactate dehydrogenase, IL-6, and lipid peroxidation, as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated rats. Moreover, it reduced peak systolic velocity and end-diastolic velocity while increasing heart rate. Arsenic trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin treatment. Conclusions: Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats. Therefore, it can be further explored as a cardioprotective agent.http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=4;spage=156;epage=164;aulast=Khuntiaarsenic trioxide; hesperidin; cardiotoxicity; ecg; ck-mb; ldh |
| spellingShingle | Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra Subash Chandra Parija Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats Asian Pacific Journal of Tropical Biomedicine arsenic trioxide; hesperidin; cardiotoxicity; ecg; ck-mb; ldh |
| title | Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats |
| title_full | Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats |
| title_fullStr | Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats |
| title_full_unstemmed | Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats |
| title_short | Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats |
| title_sort | hesperidin attenuates arsenic trioxide induced cardiac toxicity in rats |
| topic | arsenic trioxide; hesperidin; cardiotoxicity; ecg; ck-mb; ldh |
| url | http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=4;spage=156;epage=164;aulast=Khuntia |
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