Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

We find that variation in the dbt-1 gene underlies natural differences in Caenorhabditis elegans responses to the toxin arsenic. This gene encodes the E2 subunit of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, a core component of branched-chain amino acid (BCAA) metabolism. We causa...

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Bibliographic Details
Main Authors: Stefan Zdraljevic, Bennett William Fox, Christine Strand, Oishika Panda, Francisco J Tenjo, Shannon C Brady, Tim A Crombie, John G Doench, Frank C Schroeder, Erik C Andersen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
human cell lines
environmental toxin
natural variation
Online Access:https://elifesciences.org/articles/40260

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