Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism
We find that variation in the dbt-1 gene underlies natural differences in Caenorhabditis elegans responses to the toxin arsenic. This gene encodes the E2 subunit of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, a core component of branched-chain amino acid (BCAA) metabolism. We causa...
Main Authors: | Stefan Zdraljevic, Bennett William Fox, Christine Strand, Oishika Panda, Francisco J Tenjo, Shannon C Brady, Tim A Crombie, John G Doench, Frank C Schroeder, Erik C Andersen |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-04-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/40260 |
Similar Items
-
Chemosensation of Bacterial Secondary Metabolites Modulates Neuroendocrine Signaling and Behavior of C. elegans
by: Panda, Oishika, et al.
Published: (2017) -
Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations
by: Tim A Crombie, et al.
Published: (2019-12-01) -
Tightly linked antagonistic‐effect loci underlie polygenic phenotypic variation in C. elegans
by: Max R. Bernstein, et al.
Published: (2019-10-01) -
Sex-specificity of the C. elegans metabolome
by: Russell N. Burkhardt, et al.
Published: (2023-01-01) -
Arsenic Exposure and Breast Cancer Risk: A Re-Evaluation of the Literature
by: Katherine Pullella, et al.
Published: (2020-10-01)