Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds
This work includes the synthesis of some new five- seven heterocyclic rings derived from benzenesulfonylhydrazide as starting material. Its condensation with 4-methoxy and 4nitro benzaldehyde gives the Schiff bases (1a,b). Schiff bases were reacted with cyclic anhydrides given Oxazepine, Thiaz...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2017-04-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/340 |
| _version_ | 1828825016581488640 |
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| author | Ismaeel Y. Majeed Shimaa A. Saoud Ahmed A. Ahmed Eman F. Mustafa |
| author_facet | Ismaeel Y. Majeed Shimaa A. Saoud Ahmed A. Ahmed Eman F. Mustafa |
| author_sort | Ismaeel Y. Majeed |
| collection | DOAJ |
| description |
This work includes the synthesis of some new five- seven heterocyclic rings derived from benzenesulfonylhydrazide as starting material. Its condensation with 4-methoxy and 4nitro benzaldehyde gives the Schiff bases (1a,b). Schiff bases were reacted with cyclic anhydrides given Oxazepine, Thiazepine derivatives(2,3,4 a,b)(seven membered ring) and with 2-mercapto benzoic acid gives thiazine derivatives (6a,b)(six membered ring) finally with thioglycolic acid give thiazolidine ring(five membered ring) scheme(3). The synthesized compounds have been characterized by melting points,FT-IR, 1H-NMR spectroscopy ,13CNMR and Elemental analysis. some of synthesized compounds were tested for their antibacterial activity against staphylococcus aureus, pseudomonous aureous and Escherichia coli .The results showed good efficacy against these types of bacteria.
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| first_indexed | 2024-12-12T14:09:24Z |
| format | Article |
| id | doaj.art-399f7f5cb8844657946a5bac43f835c6 |
| institution | Directory Open Access Journal |
| issn | 1609-4042 2521-3407 |
| language | English |
| last_indexed | 2024-12-12T14:09:24Z |
| publishDate | 2017-04-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj.art-399f7f5cb8844657946a5bac43f835c62022-12-22T00:22:08ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072017-04-01272Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide CompoundsIsmaeel Y. MajeedShimaa A. SaoudAhmed A. AhmedEman F. Mustafa This work includes the synthesis of some new five- seven heterocyclic rings derived from benzenesulfonylhydrazide as starting material. Its condensation with 4-methoxy and 4nitro benzaldehyde gives the Schiff bases (1a,b). Schiff bases were reacted with cyclic anhydrides given Oxazepine, Thiazepine derivatives(2,3,4 a,b)(seven membered ring) and with 2-mercapto benzoic acid gives thiazine derivatives (6a,b)(six membered ring) finally with thioglycolic acid give thiazolidine ring(five membered ring) scheme(3). The synthesized compounds have been characterized by melting points,FT-IR, 1H-NMR spectroscopy ,13CNMR and Elemental analysis. some of synthesized compounds were tested for their antibacterial activity against staphylococcus aureus, pseudomonous aureous and Escherichia coli .The results showed good efficacy against these types of bacteria. https://jih.uobaghdad.edu.iq/index.php/j/article/view/340sulfonamide, Oxazepine, Thiazepine, Thiazine, Thiazolidine, Schiff bases, Antibacterial activity. |
| spellingShingle | Ismaeel Y. Majeed Shimaa A. Saoud Ahmed A. Ahmed Eman F. Mustafa Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds Ibn Al-Haitham Journal for Pure and Applied Sciences sulfonamide, Oxazepine, Thiazepine, Thiazine, Thiazolidine, Schiff bases, Antibacterial activity. |
| title | Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds |
| title_full | Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds |
| title_fullStr | Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds |
| title_full_unstemmed | Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds |
| title_short | Synthesis, Characterization and Antibacterial Activity of Some New Five-Seven Membered Rings Attached to Sulfonamide Compounds |
| title_sort | synthesis characterization and antibacterial activity of some new five seven membered rings attached to sulfonamide compounds |
| topic | sulfonamide, Oxazepine, Thiazepine, Thiazine, Thiazolidine, Schiff bases, Antibacterial activity. |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/340 |
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