Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses
Oncolytic viruses kill cancer cells by direct lysis but also generate a significant anti-tumor immune response that allows for prolonged cancer control and in some cases cures. How to best stimulate this effect is a subject of intense investigation in the oncolytic virus field. While pharmacological...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00191/full |
| _version_ | 1818890115243573248 |
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| author | Nicole E. Forbes Nicole E. Forbes Ramya eKrishnan Ramya eKrishnan Jean-Simon eDiallo Jean-Simon eDiallo |
| author_facet | Nicole E. Forbes Nicole E. Forbes Ramya eKrishnan Ramya eKrishnan Jean-Simon eDiallo Jean-Simon eDiallo |
| author_sort | Nicole E. Forbes |
| collection | DOAJ |
| description | Oncolytic viruses kill cancer cells by direct lysis but also generate a significant anti-tumor immune response that allows for prolonged cancer control and in some cases cures. How to best stimulate this effect is a subject of intense investigation in the oncolytic virus field. While pharmacological manipulation of the cellular innate antiviral immune response has been shown by several groups to improve viral oncolysis and spread, it is increasingly clear that pharmacological agents can also impact the anti-tumor immune response generated by oncolytic viruses and related tumor vaccination strategies. This review covers recent progress in using pharmacological agents to improve the activity of oncolytic viruses and their ability to generate robust anti-tumor immune responses. |
| first_indexed | 2024-12-19T17:19:47Z |
| format | Article |
| id | doaj.art-399fe5a0f1294faf89f26ecbffd8d930 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T17:19:47Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-399fe5a0f1294faf89f26ecbffd8d9302022-12-21T20:12:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-07-01410.3389/fonc.2014.00191102305Pharmacological modulation of anti-tumor immunity induced by oncolytic virusesNicole E. Forbes0Nicole E. Forbes1Ramya eKrishnan2Ramya eKrishnan3Jean-Simon eDiallo4Jean-Simon eDiallo5Ottawa Hospital Research InstituteUniversity of OttawaOttawa Hospital Research InstituteUniversity of OttawaOttawa Hospital Research InstituteUniversity of OttawaOncolytic viruses kill cancer cells by direct lysis but also generate a significant anti-tumor immune response that allows for prolonged cancer control and in some cases cures. How to best stimulate this effect is a subject of intense investigation in the oncolytic virus field. While pharmacological manipulation of the cellular innate antiviral immune response has been shown by several groups to improve viral oncolysis and spread, it is increasingly clear that pharmacological agents can also impact the anti-tumor immune response generated by oncolytic viruses and related tumor vaccination strategies. This review covers recent progress in using pharmacological agents to improve the activity of oncolytic viruses and their ability to generate robust anti-tumor immune responses.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00191/fullOncolytic VirotherapyCancerchemotherapycombination therapyanti-tumor immunityImmunomodulatory therapy |
| spellingShingle | Nicole E. Forbes Nicole E. Forbes Ramya eKrishnan Ramya eKrishnan Jean-Simon eDiallo Jean-Simon eDiallo Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses Frontiers in Oncology Oncolytic Virotherapy Cancer chemotherapy combination therapy anti-tumor immunity Immunomodulatory therapy |
| title | Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses |
| title_full | Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses |
| title_fullStr | Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses |
| title_full_unstemmed | Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses |
| title_short | Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses |
| title_sort | pharmacological modulation of anti tumor immunity induced by oncolytic viruses |
| topic | Oncolytic Virotherapy Cancer chemotherapy combination therapy anti-tumor immunity Immunomodulatory therapy |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00191/full |
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