Ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with Crohn’s disease
Pyoderma gangrenosum (PG) is an auto-inflammatory dermatosis characterized by lesions that often cause ulcers. We present a case of successful ustekinumab treatment for acute general PG in a 31-year-old woman with coexisting Crohn's disease (CD). For a month, the patient suffered from skin ulc...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-05-01
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| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/9630 |
| _version_ | 1827941815940022272 |
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| author | Klaudia Miklusiak Karol Miklusiak Olga Kaczmarczyk Dorota Cibor Małgorzata Zwolińska-Wcisło |
| author_facet | Klaudia Miklusiak Karol Miklusiak Olga Kaczmarczyk Dorota Cibor Małgorzata Zwolińska-Wcisło |
| author_sort | Klaudia Miklusiak |
| collection | DOAJ |
| description |
Pyoderma gangrenosum (PG) is an auto-inflammatory dermatosis characterized by lesions that often cause ulcers. We present a case of successful ustekinumab treatment for acute general PG in a 31-year-old woman with coexisting Crohn's disease (CD). For a month, the patient suffered from skin ulcers, two of them deep and necrotic; a histopathological examination revealed PG. Treatment included: methylprednisolone, azathioprine, betamethasone, gentamicin and zincic ointments, antiseptic compresses and adalimumab therapy. Due to resistance to the implemented treatment, the patient was enrolled in a clinical trial that included the administration of a novel anti-cytokines drug - ustekinumab. Subsequently, a significant reduction was observed in the severity of symptoms of PG and CD, with no relapse. The use of ustekinumab in patients with PG who have an inadequate response to current treatment or cannot receive first-line treatment can be considered. This applies especially to patients with accompanying autoimmune diseases such as CD.
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| first_indexed | 2024-03-13T09:49:21Z |
| format | Article |
| id | doaj.art-39a057364cfb4d6b8acedadf7995d43d |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-03-13T09:49:21Z |
| publishDate | 2023-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-39a057364cfb4d6b8acedadf7995d43d2023-05-24T17:59:02ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062023-05-0110.4081/dr.2023.9630Ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with Crohn’s diseaseKlaudia Miklusiak0Karol Miklusiak1Olga Kaczmarczyk2Dorota Cibor3Małgorzata Zwolińska-Wcisło4Department of Gastrology and Hepatology, Medical College, Jagiellonian University, KrakowDepartment of Gastrology and Hepatology, Medical College, Jagiellonian University, KrakowDepartment of Gastrology and Hepatology, Medical College, Jagiellonian University, KrakowDepartment of Gastrology and Hepatology, Medical College, Jagiellonian University, KrakowDepartment of Gastrology and Hepatology, Medical College, Jagiellonian University, Krakow Pyoderma gangrenosum (PG) is an auto-inflammatory dermatosis characterized by lesions that often cause ulcers. We present a case of successful ustekinumab treatment for acute general PG in a 31-year-old woman with coexisting Crohn's disease (CD). For a month, the patient suffered from skin ulcers, two of them deep and necrotic; a histopathological examination revealed PG. Treatment included: methylprednisolone, azathioprine, betamethasone, gentamicin and zincic ointments, antiseptic compresses and adalimumab therapy. Due to resistance to the implemented treatment, the patient was enrolled in a clinical trial that included the administration of a novel anti-cytokines drug - ustekinumab. Subsequently, a significant reduction was observed in the severity of symptoms of PG and CD, with no relapse. The use of ustekinumab in patients with PG who have an inadequate response to current treatment or cannot receive first-line treatment can be considered. This applies especially to patients with accompanying autoimmune diseases such as CD. https://www.pagepress.org/journals/index.php/dr/article/view/9630pyoderma gangrenosumCrohn’s diseaseustekinumab |
| spellingShingle | Klaudia Miklusiak Karol Miklusiak Olga Kaczmarczyk Dorota Cibor Małgorzata Zwolińska-Wcisło Ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with Crohn’s disease Dermatology Reports pyoderma gangrenosum Crohn’s disease ustekinumab |
| title | Ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with Crohn’s disease |
| title_full | Ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with Crohn’s disease |
| title_fullStr | Ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with Crohn’s disease |
| title_full_unstemmed | Ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with Crohn’s disease |
| title_short | Ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with Crohn’s disease |
| title_sort | ustekinumab in the treatment of acute disseminated pyoderma gangrenosum in a patient with crohn s disease |
| topic | pyoderma gangrenosum Crohn’s disease ustekinumab |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/9630 |
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