Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, China
Abstract Background As a gateway for HIV-1 in China, Yunnan has experienced dramatic changes in HIV-1 epidemics, during which HIV-1 genotypes have become complex. To track dynamic changes in HIV-1 genotypes, an HIV-1 molecular epidemiological study was implemented in the recently infected population...
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BMC
2019-07-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4276-9 |
| _version_ | 1818129926234046464 |
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| author | Min Chen Yanling Ma Huichao Chen Jie Dai Hongbing Luo Chaojun Yang Lijuan Dong Xiaomei Jin Min Yang Li Yang Lijun Song Zhizhong Song Manhong Jia |
| author_facet | Min Chen Yanling Ma Huichao Chen Jie Dai Hongbing Luo Chaojun Yang Lijuan Dong Xiaomei Jin Min Yang Li Yang Lijun Song Zhizhong Song Manhong Jia |
| author_sort | Min Chen |
| collection | DOAJ |
| description | Abstract Background As a gateway for HIV-1 in China, Yunnan has experienced dramatic changes in HIV-1 epidemics, during which HIV-1 genotypes have become complex. To track dynamic changes in HIV-1 genotypes, an HIV-1 molecular epidemiological study was implemented in the recently infected population in Yunnan. Methods From 6,357 HIV-1-positive samples diagnosed during the first half of 2015 in Yunnan, 586 samples were identified as recent infections with BED-capture enzyme immunoassay (CEIA) and were subjected to phylogenetic analyses. Spatial scanning analyses for the main HIV-1 genotypes were also performed. Results Among the 439 specimens successfully genotyped, more than ten genotypes were detected, including CRF08_BC (45.3%), CRF07_BC (19.4%), unique recombinant forms (URFs) (18.2%), CRF01_AE (11.4%), subtype C (2.1%), CRF85_BC (1.1%), CRF55_01B (0.9%), subtype B (0.5%), CRF64_BC (0.5%), CRF59_01B (0.2%), CRF83_cpx (0.2%) and CRF87_cpx (0.2%). Females, Chinese, heterosexual contact and intravenous drug injection were significantly associated with CRF08_BC infection; homosexual contact was significantly associated with CRF01_AE and CRF07_BC infection; males and non-Chinese had a higher risk of URF infection than females. Among all HIV-1 genotypes, the geographic coverage of CRF08_BC was the largest. For CRF08_BC, CRF07_BC, URFs and CRF01_AE, spatial clusters were detected. The two CRF08_BC clusters and one URF cluster were associated with heterosexual transmission, and two of CRF01_AE clusters were associated with homosexual transmission. Transmitted drug resistance (TDR)-associated mutations were detected in 2.4% of individuals. Conclusions The diversity of HIV-1 genotypes increased in recent infections because of a long-term HIV-1 epidemic in Yunnan. The predominant HIV-1 strains showed distinct demographic characteristics and formed spatial clusters. These findings improved our understanding of the evolution of HIV-1 in Yunnan and provided information for further HIV-1 control and prevention. |
| first_indexed | 2024-12-11T07:56:54Z |
| format | Article |
| id | doaj.art-39a0a8d77ba5422abde51cf3223d0e84 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-11T07:56:54Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-39a0a8d77ba5422abde51cf3223d0e842022-12-22T01:15:12ZengBMCBMC Infectious Diseases1471-23342019-07-0119111310.1186/s12879-019-4276-9Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, ChinaMin Chen0Yanling Ma1Huichao Chen2Jie Dai3Hongbing Luo4Chaojun Yang5Lijuan Dong6Xiaomei Jin7Min Yang8Li Yang9Lijun Song10Zhizhong Song11Manhong Jia12Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and PreventionAbstract Background As a gateway for HIV-1 in China, Yunnan has experienced dramatic changes in HIV-1 epidemics, during which HIV-1 genotypes have become complex. To track dynamic changes in HIV-1 genotypes, an HIV-1 molecular epidemiological study was implemented in the recently infected population in Yunnan. Methods From 6,357 HIV-1-positive samples diagnosed during the first half of 2015 in Yunnan, 586 samples were identified as recent infections with BED-capture enzyme immunoassay (CEIA) and were subjected to phylogenetic analyses. Spatial scanning analyses for the main HIV-1 genotypes were also performed. Results Among the 439 specimens successfully genotyped, more than ten genotypes were detected, including CRF08_BC (45.3%), CRF07_BC (19.4%), unique recombinant forms (URFs) (18.2%), CRF01_AE (11.4%), subtype C (2.1%), CRF85_BC (1.1%), CRF55_01B (0.9%), subtype B (0.5%), CRF64_BC (0.5%), CRF59_01B (0.2%), CRF83_cpx (0.2%) and CRF87_cpx (0.2%). Females, Chinese, heterosexual contact and intravenous drug injection were significantly associated with CRF08_BC infection; homosexual contact was significantly associated with CRF01_AE and CRF07_BC infection; males and non-Chinese had a higher risk of URF infection than females. Among all HIV-1 genotypes, the geographic coverage of CRF08_BC was the largest. For CRF08_BC, CRF07_BC, URFs and CRF01_AE, spatial clusters were detected. The two CRF08_BC clusters and one URF cluster were associated with heterosexual transmission, and two of CRF01_AE clusters were associated with homosexual transmission. Transmitted drug resistance (TDR)-associated mutations were detected in 2.4% of individuals. Conclusions The diversity of HIV-1 genotypes increased in recent infections because of a long-term HIV-1 epidemic in Yunnan. The predominant HIV-1 strains showed distinct demographic characteristics and formed spatial clusters. These findings improved our understanding of the evolution of HIV-1 in Yunnan and provided information for further HIV-1 control and prevention.http://link.springer.com/article/10.1186/s12879-019-4276-9Human immunodeficiency virus-1 (HIV-1)GeneticsRecent infectionsSpatial clusterChina |
| spellingShingle | Min Chen Yanling Ma Huichao Chen Jie Dai Hongbing Luo Chaojun Yang Lijuan Dong Xiaomei Jin Min Yang Li Yang Lijun Song Zhizhong Song Manhong Jia Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, China BMC Infectious Diseases Human immunodeficiency virus-1 (HIV-1) Genetics Recent infections Spatial cluster China |
| title | Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, China |
| title_full | Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, China |
| title_fullStr | Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, China |
| title_full_unstemmed | Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, China |
| title_short | Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, China |
| title_sort | spatial clusters of hiv 1 genotypes in a recently infected population in yunnan china |
| topic | Human immunodeficiency virus-1 (HIV-1) Genetics Recent infections Spatial cluster China |
| url | http://link.springer.com/article/10.1186/s12879-019-4276-9 |
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