Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways

Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways

The mechanisms by which myelodysplastic syndrome (MDS) cells resist the effects of hypomethylating agents (HMA) are currently the subject of intensive research. A better understanding of mechanisms by which the MDS cell becomes to tolerate HMA and progresses to acute myeloid leukemia (AML) requires...

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Main Authors: Lubomír Minařík, Kristýna Pimková, Juraj Kokavec, Adéla Schaffartziková, Fréderic Vellieux, Vojtěch Kulvait, Lenka Daumová, Nina Dusilková, Anna Jonášová, Karina Savvulidi Vargová, Petra Králová Viziová, Radislav Sedláček, Zuzana Zemanová, Tomáš Stopka
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
myelodysplastic syndrome
Azacytidine
resistance
CDX mice
PI3K/AKT signaling
Online Access:https://www.mdpi.com/2073-4409/11/2/223

Internet

https://www.mdpi.com/2073-4409/11/2/223

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