Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease
Abstract This study investigated whether the progression of liver fibrosis affects the prevalence of sarcopenia and incidence of decreased gait speed in older patients with chronic liver disease (CLD). Patients with CLD aged ≥ 60 years were classified into low, intermediate, and high fibrosis 4 (FIB...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-57342-1 |
| _version_ | 1797247322441121792 |
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| author | Kenichi Fudeyasu Kai Ushio Takuo Nomura Toshihiro Kawae Daisuke Iwaki Yuki Nakashima Akiko Nagao Akira Hiramatsu Eisuke Murakami Shiro Oka Yukio Mikami |
| author_facet | Kenichi Fudeyasu Kai Ushio Takuo Nomura Toshihiro Kawae Daisuke Iwaki Yuki Nakashima Akiko Nagao Akira Hiramatsu Eisuke Murakami Shiro Oka Yukio Mikami |
| author_sort | Kenichi Fudeyasu |
| collection | DOAJ |
| description | Abstract This study investigated whether the progression of liver fibrosis affects the prevalence of sarcopenia and incidence of decreased gait speed in older patients with chronic liver disease (CLD). Patients with CLD aged ≥ 60 years were classified into low, intermediate, and high fibrosis 4 (FIB-4) index groups according to the degree of liver fibrosis. The prevalence of sarcopenia and incidence of decreased gait speed (< 1.0 m/s) were compared among the three groups. Logistic regression analysis was performed to investigate factors affecting the risk of decreased gait speed. No significant difference was observed in the prevalence of sarcopenia among the three groups, but the incidence of decreased gait speed significantly differed (p = 0.029). When analyzed individually, a significant difference in decreased gait speed incidence was observed between the high and low FIB-4 index groups (p = 0.014). In logistic regression analysis, the progression of liver fibrosis (odds ratio: 1.32, 95% confidence interval: 1.13–1.55) and lower extremity muscle strength (LEMS) (odds ratio: 0.92, 95% confidence interval: 0.88–0.97) were significantly associated with decreased gait speed. As liver fibrosis progresses in older patients with CLD, it becomes important to focus on not only skeletal muscle mass and grip strength, but also gait speed and LEMS. |
| first_indexed | 2024-04-24T19:56:51Z |
| format | Article |
| id | doaj.art-39a2470bcf31452e89431e643e16c992 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T19:56:51Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-39a2470bcf31452e89431e643e16c9922024-03-24T12:17:03ZengNature PortfolioScientific Reports2045-23222024-03-0114111010.1038/s41598-024-57342-1Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver diseaseKenichi Fudeyasu0Kai Ushio1Takuo Nomura2Toshihiro Kawae3Daisuke Iwaki4Yuki Nakashima5Akiko Nagao6Akira Hiramatsu7Eisuke Murakami8Shiro Oka9Yukio Mikami10Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University HospitalDepartment of Rehabilitation Medicine, Hiroshima University HospitalDepartment of Physical Therapy, Faculty of Rehabilitation, Kansai Medical UniversityDepartment of Physical Therapy, Makuhari Human Care Faculty, Tohto UniversityDivision of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University HospitalDivision of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University HospitalDivision of Nutrition Management, Hiroshima University HospitalDepartment of Gastroenterology, KKR Hiroshima Memorial HospitalDepartment of Gastroenterology, Hiroshima University HospitalDepartment of Gastroenterology, Hiroshima University HospitalDepartment of Rehabilitation Medicine, Hiroshima University HospitalAbstract This study investigated whether the progression of liver fibrosis affects the prevalence of sarcopenia and incidence of decreased gait speed in older patients with chronic liver disease (CLD). Patients with CLD aged ≥ 60 years were classified into low, intermediate, and high fibrosis 4 (FIB-4) index groups according to the degree of liver fibrosis. The prevalence of sarcopenia and incidence of decreased gait speed (< 1.0 m/s) were compared among the three groups. Logistic regression analysis was performed to investigate factors affecting the risk of decreased gait speed. No significant difference was observed in the prevalence of sarcopenia among the three groups, but the incidence of decreased gait speed significantly differed (p = 0.029). When analyzed individually, a significant difference in decreased gait speed incidence was observed between the high and low FIB-4 index groups (p = 0.014). In logistic regression analysis, the progression of liver fibrosis (odds ratio: 1.32, 95% confidence interval: 1.13–1.55) and lower extremity muscle strength (LEMS) (odds ratio: 0.92, 95% confidence interval: 0.88–0.97) were significantly associated with decreased gait speed. As liver fibrosis progresses in older patients with CLD, it becomes important to focus on not only skeletal muscle mass and grip strength, but also gait speed and LEMS.https://doi.org/10.1038/s41598-024-57342-1Gait speedLiver diseaseLiver fibrosisMuscle strengthSarcopenia |
| spellingShingle | Kenichi Fudeyasu Kai Ushio Takuo Nomura Toshihiro Kawae Daisuke Iwaki Yuki Nakashima Akiko Nagao Akira Hiramatsu Eisuke Murakami Shiro Oka Yukio Mikami Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease Scientific Reports Gait speed Liver disease Liver fibrosis Muscle strength Sarcopenia |
| title | Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease |
| title_full | Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease |
| title_fullStr | Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease |
| title_full_unstemmed | Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease |
| title_short | Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease |
| title_sort | advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease |
| topic | Gait speed Liver disease Liver fibrosis Muscle strength Sarcopenia |
| url | https://doi.org/10.1038/s41598-024-57342-1 |
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