Biological Activities and Composition of Ferulago carduchorum Essential Oil
Background: Ferulago carduchorum Boiss and Hausskn belongs to the Apiaceae family. This plant grows in west part of Iran that local people added it to dairy and oil ghee to delay expiration date and give them a pleasant taste. The aim of this study was to investigate the antioxidant, antimicrobial,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2015-10-01
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| Series: | Journal of Arthropod-Borne Diseases |
| Subjects: | |
| Online Access: | https://jad.tums.ac.ir/index.php/jad/article/view/122 |
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| author | Fereshteh Golfakhrabadi Mahnaz Khanavi SeyedNasser Ostad Soodabeh Saeidnia Hassan Vatandoost MohammadReza Abai Mitra Hafizi Fatemeh Yousefbeyk Yaghoob RazzaghiRad Ameneh Baghenegadian MohammadReza Shams-Ardekani |
| author_facet | Fereshteh Golfakhrabadi Mahnaz Khanavi SeyedNasser Ostad Soodabeh Saeidnia Hassan Vatandoost MohammadReza Abai Mitra Hafizi Fatemeh Yousefbeyk Yaghoob RazzaghiRad Ameneh Baghenegadian MohammadReza Shams-Ardekani |
| author_sort | Fereshteh Golfakhrabadi |
| collection | DOAJ |
| description | Background: Ferulago carduchorum Boiss and Hausskn belongs to the Apiaceae family. This plant grows in west part of Iran that local people added it to dairy and oil ghee to delay expiration date and give them a pleasant taste. The aim of this study was to investigate the antioxidant, antimicrobial, acetyl cholinesterase inhibition, cytotoxic, larvicidal activities and composition of essential oil of F. carduchorum.
Methods: Acetyl cholinesterase (AChE) inhibitory, larvicidal activities and chemical composition of essential oil of F. carduchorum were investigated. Besides, antioxidant, antimicrobial and cytotoxic activities of essential oil were tested using DPPH, microdilution method and MTT assay, respectively.
Results: The major components of essential oil were (z)-β-ocimene (43.3%), α-pinene (18.23%) and bornyl acetate (3.98%). Among 43 identified components, monoterpenes were the most compounds (84.63%). The essential oil had noticeable efficiency against Candida albicans (MIC= 2340 μg ml-1) and it was effective against Anopheles
stephensi with LC50 and LC90 values of 12.78 and 47.43 ppm, respectively. The essential oil could inhibit AChE (IC50= 23.6 μl ml-1). The essential oil showed high cytotoxicity on T47D, HEP-G2 and HT-29 cell lines (IC50< 2 μg ml-1).
Conclusion: The essential oil of F. carduchorum collected from west of Iran had anti-Candida, larvicidal and cytotoxicity effects and should be further investigated in others in vitro and in vivo experimental models. |
| first_indexed | 2024-12-13T23:39:37Z |
| format | Article |
| id | doaj.art-39a51e4393df429092af3dba7e696e58 |
| institution | Directory Open Access Journal |
| issn | 1735-7179 2322-2271 |
| language | English |
| last_indexed | 2024-12-13T23:39:37Z |
| publishDate | 2015-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Arthropod-Borne Diseases |
| spelling | doaj.art-39a51e4393df429092af3dba7e696e582022-12-21T23:27:11ZengTehran University of Medical SciencesJournal of Arthropod-Borne Diseases1735-71792322-22712015-10-0191110Biological Activities and Composition of Ferulago carduchorum Essential OilFereshteh Golfakhrabadi0Mahnaz Khanavi1SeyedNasser Ostad2Soodabeh Saeidnia3Hassan Vatandoost4MohammadReza Abai5Mitra Hafizi6Fatemeh Yousefbeyk7Yaghoob RazzaghiRad8Ameneh Baghenegadian9MohammadReza Shams-Ardekani10Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran AND Department of Traditional Pharmacy, Faculty of Traditional Medicine and Persian Medicine AND Pharmacy Research Center, Tehran University of Medical Sciences,Tehran, Iran.Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran AND Department of Traditional Pharmacy, Faculty of Traditional Medicine and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.Background: Ferulago carduchorum Boiss and Hausskn belongs to the Apiaceae family. This plant grows in west part of Iran that local people added it to dairy and oil ghee to delay expiration date and give them a pleasant taste. The aim of this study was to investigate the antioxidant, antimicrobial, acetyl cholinesterase inhibition, cytotoxic, larvicidal activities and composition of essential oil of F. carduchorum. Methods: Acetyl cholinesterase (AChE) inhibitory, larvicidal activities and chemical composition of essential oil of F. carduchorum were investigated. Besides, antioxidant, antimicrobial and cytotoxic activities of essential oil were tested using DPPH, microdilution method and MTT assay, respectively. Results: The major components of essential oil were (z)-β-ocimene (43.3%), α-pinene (18.23%) and bornyl acetate (3.98%). Among 43 identified components, monoterpenes were the most compounds (84.63%). The essential oil had noticeable efficiency against Candida albicans (MIC= 2340 μg ml-1) and it was effective against Anopheles stephensi with LC50 and LC90 values of 12.78 and 47.43 ppm, respectively. The essential oil could inhibit AChE (IC50= 23.6 μl ml-1). The essential oil showed high cytotoxicity on T47D, HEP-G2 and HT-29 cell lines (IC50< 2 μg ml-1). Conclusion: The essential oil of F. carduchorum collected from west of Iran had anti-Candida, larvicidal and cytotoxicity effects and should be further investigated in others in vitro and in vivo experimental models.https://jad.tums.ac.ir/index.php/jad/article/view/122Ferulago carduchorumEssential oilAntimicrobialAntiacetyl cholinesteraseLarvicidal activity |
| spellingShingle | Fereshteh Golfakhrabadi Mahnaz Khanavi SeyedNasser Ostad Soodabeh Saeidnia Hassan Vatandoost MohammadReza Abai Mitra Hafizi Fatemeh Yousefbeyk Yaghoob RazzaghiRad Ameneh Baghenegadian MohammadReza Shams-Ardekani Biological Activities and Composition of Ferulago carduchorum Essential Oil Journal of Arthropod-Borne Diseases Ferulago carduchorum Essential oil Antimicrobial Antiacetyl cholinesterase Larvicidal activity |
| title | Biological Activities and Composition of Ferulago carduchorum Essential Oil |
| title_full | Biological Activities and Composition of Ferulago carduchorum Essential Oil |
| title_fullStr | Biological Activities and Composition of Ferulago carduchorum Essential Oil |
| title_full_unstemmed | Biological Activities and Composition of Ferulago carduchorum Essential Oil |
| title_short | Biological Activities and Composition of Ferulago carduchorum Essential Oil |
| title_sort | biological activities and composition of ferulago carduchorum essential oil |
| topic | Ferulago carduchorum Essential oil Antimicrobial Antiacetyl cholinesterase Larvicidal activity |
| url | https://jad.tums.ac.ir/index.php/jad/article/view/122 |
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