Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context
Endometrial cancer (EC) is the most common gynaecological malignancy in the developed world, and concerningly incidence is rising, particularly in younger people. Therefore, there is increased interest in novel diagnostic and prognostic biomarkers. Extracellular vesicles (EVs) are membrane-bound par...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523322001371 |
| _version_ | 1818108547915841536 |
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| author | Emily Paterson Cherie Blenkiron Kirsty Danielson Claire Henry |
| author_facet | Emily Paterson Cherie Blenkiron Kirsty Danielson Claire Henry |
| author_sort | Emily Paterson |
| collection | DOAJ |
| description | Endometrial cancer (EC) is the most common gynaecological malignancy in the developed world, and concerningly incidence is rising, particularly in younger people. Therefore, there is increased interest in novel diagnostic and prognostic biomarkers. Extracellular vesicles (EVs) are membrane-bound particles present in bodily fluids that have the potential to facilitate non-invasive, early diagnosis of EC and could aid with monitoring of recurrence and treatment response. EV cargo provides molecular insight into the tumor, with the lipid bilayer providing stability for RNA species usually prone to degradation. miRNAs have recently become a focus for EV biomarker research due to their ability to regulate cancer related pathways and influence cancer development and progression. This review evaluates the current literature on EV miRNA biomarkers with a focus on EC, and discusses the challenges facing this research. This review finally highlights areas of focus for EV miRNA biomarker research going forward, such as standardization of normalization approaches, sample storage and processing, extensive reporting of methodologies and moving away from single miRNA biomarkers. |
| first_indexed | 2024-12-11T02:17:06Z |
| format | Article |
| id | doaj.art-39a5ac65d2b3480aaa2014def21ea304 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-11T02:17:06Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-39a5ac65d2b3480aaa2014def21ea3042022-12-22T01:24:10ZengElsevierTranslational Oncology1936-52332022-09-0123101478Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer contextEmily Paterson0Cherie Blenkiron1Kirsty Danielson2Claire Henry3Department of Obstetrics, Gynaecology and Women's Health, University of Otago, Wellington, New ZealandFaculty of Medical and Health Sciences, University of Auckland, Auckland, New ZealandDepartment of Surgery and Anaesthesia, University of Otago, Wellington, New ZealandDepartment of Obstetrics, Gynaecology and Women's Health, University of Otago, Wellington, New Zealand; Corresponding author.Endometrial cancer (EC) is the most common gynaecological malignancy in the developed world, and concerningly incidence is rising, particularly in younger people. Therefore, there is increased interest in novel diagnostic and prognostic biomarkers. Extracellular vesicles (EVs) are membrane-bound particles present in bodily fluids that have the potential to facilitate non-invasive, early diagnosis of EC and could aid with monitoring of recurrence and treatment response. EV cargo provides molecular insight into the tumor, with the lipid bilayer providing stability for RNA species usually prone to degradation. miRNAs have recently become a focus for EV biomarker research due to their ability to regulate cancer related pathways and influence cancer development and progression. This review evaluates the current literature on EV miRNA biomarkers with a focus on EC, and discusses the challenges facing this research. This review finally highlights areas of focus for EV miRNA biomarker research going forward, such as standardization of normalization approaches, sample storage and processing, extensive reporting of methodologies and moving away from single miRNA biomarkers.http://www.sciencedirect.com/science/article/pii/S1936523322001371Extracellular vesiclesmiRNAsBiomarkersEndometrial cancer |
| spellingShingle | Emily Paterson Cherie Blenkiron Kirsty Danielson Claire Henry Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context Translational Oncology Extracellular vesicles miRNAs Biomarkers Endometrial cancer |
| title | Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context |
| title_full | Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context |
| title_fullStr | Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context |
| title_full_unstemmed | Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context |
| title_short | Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context |
| title_sort | recommendations for extracellular vesicle mirna biomarker research in the endometrial cancer context |
| topic | Extracellular vesicles miRNAs Biomarkers Endometrial cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1936523322001371 |
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