Global patterns of sequence evolution in <it>Drosophila</it>
<p>Abstract</p> <p>Background</p> <p>Sequencing of the genomes of several <it>Drosophila </it>allows for the first precise analyses of how global sequence patterns change among multiple, closely related animal species. A basic question is whether there are c...
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| Format: | Article |
| Language: | English |
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BMC
2007-11-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/8/408 |
| _version_ | 1811248121457410048 |
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| author | Marín Ignacio Arnau Vicente Gallach Miguel |
| author_facet | Marín Ignacio Arnau Vicente Gallach Miguel |
| author_sort | Marín Ignacio |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Sequencing of the genomes of several <it>Drosophila </it>allows for the first precise analyses of how global sequence patterns change among multiple, closely related animal species. A basic question is whether there are characteristic features that differentiate chromosomes within a species or between different species.</p> <p>Results</p> <p>We explored the euchromatin of the chromosomes of seven <it>Drosophila </it>species to establish their global patterns of DNA sequence diversity. Between species, differences in the types and amounts of simple sequence repeats were found. Within each species, the autosomes have almost identical oligonucleotide profiles. However, X chromosomes and autosomes have, in all species, a qualitatively different composition. The X chromosomes are less complex than the autosomes, containing both a higher amount of simple DNA sequences and, in several cases, chromosome-specific repetitive sequences. Moreover, we show that the right arm of the X chromosome of <it>Drosophila pseudoobscura</it>, which evolved from an autosome 10 – 18 millions of years ago, has a composition which is identical to that of the original, left arm of the X chromosome.</p> <p>Conclusion</p> <p>The consistent differences among species, differences among X chromosomes and autosomes and the convergent evolution of X and neo-X chromosomes demonstrate that strong forces are acting on drosophilid genomes to generate peculiar chromosomal landscapes. We discuss the relationships of the patterns observed with differential recombination and mutation rates and with the process of dosage compensation.</p> |
| first_indexed | 2024-04-12T15:21:30Z |
| format | Article |
| id | doaj.art-39a6ccd679c14bb284847334a864333b |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-04-12T15:21:30Z |
| publishDate | 2007-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-39a6ccd679c14bb284847334a864333b2022-12-22T03:27:24ZengBMCBMC Genomics1471-21642007-11-018140810.1186/1471-2164-8-408Global patterns of sequence evolution in <it>Drosophila</it>Marín IgnacioArnau VicenteGallach Miguel<p>Abstract</p> <p>Background</p> <p>Sequencing of the genomes of several <it>Drosophila </it>allows for the first precise analyses of how global sequence patterns change among multiple, closely related animal species. A basic question is whether there are characteristic features that differentiate chromosomes within a species or between different species.</p> <p>Results</p> <p>We explored the euchromatin of the chromosomes of seven <it>Drosophila </it>species to establish their global patterns of DNA sequence diversity. Between species, differences in the types and amounts of simple sequence repeats were found. Within each species, the autosomes have almost identical oligonucleotide profiles. However, X chromosomes and autosomes have, in all species, a qualitatively different composition. The X chromosomes are less complex than the autosomes, containing both a higher amount of simple DNA sequences and, in several cases, chromosome-specific repetitive sequences. Moreover, we show that the right arm of the X chromosome of <it>Drosophila pseudoobscura</it>, which evolved from an autosome 10 – 18 millions of years ago, has a composition which is identical to that of the original, left arm of the X chromosome.</p> <p>Conclusion</p> <p>The consistent differences among species, differences among X chromosomes and autosomes and the convergent evolution of X and neo-X chromosomes demonstrate that strong forces are acting on drosophilid genomes to generate peculiar chromosomal landscapes. We discuss the relationships of the patterns observed with differential recombination and mutation rates and with the process of dosage compensation.</p>http://www.biomedcentral.com/1471-2164/8/408 |
| spellingShingle | Marín Ignacio Arnau Vicente Gallach Miguel Global patterns of sequence evolution in <it>Drosophila</it> BMC Genomics |
| title | Global patterns of sequence evolution in <it>Drosophila</it> |
| title_full | Global patterns of sequence evolution in <it>Drosophila</it> |
| title_fullStr | Global patterns of sequence evolution in <it>Drosophila</it> |
| title_full_unstemmed | Global patterns of sequence evolution in <it>Drosophila</it> |
| title_short | Global patterns of sequence evolution in <it>Drosophila</it> |
| title_sort | global patterns of sequence evolution in it drosophila it |
| url | http://www.biomedcentral.com/1471-2164/8/408 |
| work_keys_str_mv | AT marinignacio globalpatternsofsequenceevolutioninitdrosophilait AT arnauvicente globalpatternsofsequenceevolutioninitdrosophilait AT gallachmiguel globalpatternsofsequenceevolutioninitdrosophilait |