Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive status
Abstract Background In patients with Parkinson’s disease (PD), depression has a strong impact on quality of life (QoL). However, little is known about the influence of subthreshold depression (STD) on QoL in PD patients. Methods A total of 230 hospitalized PD patients with normal and impaired cognit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Health and Quality of Life Outcomes |
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| Online Access: | https://doi.org/10.1186/s12955-021-01753-5 |
| _version_ | 1818414458243907584 |
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| author | Aline Schönenberg Hannah M. Zipprich Ulrike Teschner Julian Grosskreutz Otto W. Witte Tino Prell |
| author_facet | Aline Schönenberg Hannah M. Zipprich Ulrike Teschner Julian Grosskreutz Otto W. Witte Tino Prell |
| author_sort | Aline Schönenberg |
| collection | DOAJ |
| description | Abstract Background In patients with Parkinson’s disease (PD), depression has a strong impact on quality of life (QoL). However, little is known about the influence of subthreshold depression (STD) on QoL in PD patients. Methods A total of 230 hospitalized PD patients with normal and impaired cognitive status were included in this observational study. We collected the following data for analysis: Beck Depression Inventory level, Montreal Cognitive Assessment (MOCA) score, non-motor symptoms questionnaire score, PD questionnaire-39 (PDQ-39) score, Hoehn–Yahr stage, and Movement Disorder Society-sponsored revision of the unified PD rating scale III (MDS-UPDRS III) score. To study the impact of STD on the PDQ-39 summary index (SI) and its domains, we used multivariate analysis of variance and multivariate analysis of covariance. Results In this cohort, 80 (34.8%) patients had STD [44 (32.3%) with high MOCA score (> 21) and 36 (38.3%) with low MOCA score (< 21)]. In PDQ-39 SI, there was a significant effect on depression level. In patients with higher MOCA score, STD was associated with worse PDQ-39 domains emotional well-being and cognition, whereas in patients with lower MOCA score, STD had no significant effect on PDQ-39 SI or its subdomains. Conclusion In PD patients, QoL is significantly affected by STD, and thus, more attention in medical care should be focused on treating STD. However, the impact is only observable in PD patients with normal cognitive function. STD patients show more reduced QoL than non-depressed patients, indicating that STD should be treated as a transition zone between normal mood and depression. |
| first_indexed | 2024-12-14T11:19:25Z |
| format | Article |
| id | doaj.art-39a80b20fa4f4ffb9ebf35d22eec97b2 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-12-14T11:19:25Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-39a80b20fa4f4ffb9ebf35d22eec97b22022-12-21T23:03:50ZengBMCHealth and Quality of Life Outcomes1477-75252021-03-011911810.1186/s12955-021-01753-5Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive statusAline Schönenberg0Hannah M. Zipprich1Ulrike Teschner2Julian Grosskreutz3Otto W. Witte4Tino Prell5Department of Neurology, Jena University HospitalDepartment of Neurology, Jena University HospitalDepartment of Neurology, Jena University HospitalDepartment of Neurology, Jena University HospitalDepartment of Neurology, Jena University HospitalDepartment of Neurology, Jena University HospitalAbstract Background In patients with Parkinson’s disease (PD), depression has a strong impact on quality of life (QoL). However, little is known about the influence of subthreshold depression (STD) on QoL in PD patients. Methods A total of 230 hospitalized PD patients with normal and impaired cognitive status were included in this observational study. We collected the following data for analysis: Beck Depression Inventory level, Montreal Cognitive Assessment (MOCA) score, non-motor symptoms questionnaire score, PD questionnaire-39 (PDQ-39) score, Hoehn–Yahr stage, and Movement Disorder Society-sponsored revision of the unified PD rating scale III (MDS-UPDRS III) score. To study the impact of STD on the PDQ-39 summary index (SI) and its domains, we used multivariate analysis of variance and multivariate analysis of covariance. Results In this cohort, 80 (34.8%) patients had STD [44 (32.3%) with high MOCA score (> 21) and 36 (38.3%) with low MOCA score (< 21)]. In PDQ-39 SI, there was a significant effect on depression level. In patients with higher MOCA score, STD was associated with worse PDQ-39 domains emotional well-being and cognition, whereas in patients with lower MOCA score, STD had no significant effect on PDQ-39 SI or its subdomains. Conclusion In PD patients, QoL is significantly affected by STD, and thus, more attention in medical care should be focused on treating STD. However, the impact is only observable in PD patients with normal cognitive function. STD patients show more reduced QoL than non-depressed patients, indicating that STD should be treated as a transition zone between normal mood and depression.https://doi.org/10.1186/s12955-021-01753-5Subthreshold depressionDementiaQuality of lifeParkinson’s diseaseCognitive impairmentNon-motor symptoms |
| spellingShingle | Aline Schönenberg Hannah M. Zipprich Ulrike Teschner Julian Grosskreutz Otto W. Witte Tino Prell Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive status Health and Quality of Life Outcomes Subthreshold depression Dementia Quality of life Parkinson’s disease Cognitive impairment Non-motor symptoms |
| title | Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive status |
| title_full | Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive status |
| title_fullStr | Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive status |
| title_full_unstemmed | Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive status |
| title_short | Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive status |
| title_sort | impact of subthreshold depression on health related quality of life in patients with parkinson s disease based on cognitive status |
| topic | Subthreshold depression Dementia Quality of life Parkinson’s disease Cognitive impairment Non-motor symptoms |
| url | https://doi.org/10.1186/s12955-021-01753-5 |
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