Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior
Background: Animal and epidemiological studies suggest that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may negatively impact toddler neurodevelopment. Methods: We investigated this association in 835 mother–child pairs from CANDLE, a diverse pregnancy cohort in the mid-South region...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021006644 |
| _version_ | 1818753605356748800 |
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| author | Erin R. Wallace Yu Ni Christine T. Loftus Alexis Sullivan Erin Masterson Adam A. Szpiro Drew B. Day Morgan Robinson Kurunthachalam Kannan Fran A. Tylavsky Sheela Sathyanarayana Nicole R. Bush Kaja Z. LeWinn Catherine J. Karr |
| author_facet | Erin R. Wallace Yu Ni Christine T. Loftus Alexis Sullivan Erin Masterson Adam A. Szpiro Drew B. Day Morgan Robinson Kurunthachalam Kannan Fran A. Tylavsky Sheela Sathyanarayana Nicole R. Bush Kaja Z. LeWinn Catherine J. Karr |
| author_sort | Erin R. Wallace |
| collection | DOAJ |
| description | Background: Animal and epidemiological studies suggest that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may negatively impact toddler neurodevelopment. Methods: We investigated this association in 835 mother–child pairs from CANDLE, a diverse pregnancy cohort in the mid-South region of the U.S. PAH metabolite concentrations were measured in mid-pregnancy maternal urine. Cognitive and Language composite scores at ages 2 and 3 years were derived from the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-3). Behavior Problem and Competence scores at age 2 were derived from the Brief Infant and Toddler Social Emotional Assessment (BITSEA). We used multivariate linear or Poisson regression to estimate associations with continuous scores and relative risks (RR) of neurodevelopment delay or behavior problems per 2-fold increase in PAH, adjusted for maternal health, nutrition, and socioeconomic status. Secondary analyses investigated associations with PAH mixture using Weighted Quantile Sum Regression (WQS) with a permutation test extension. Results: 1- hydroxypyrene was associated with elevated relative risk for Neurodevelopmental Delay at age 2 (RR = 1.20, 95% CI: 1.03,1.39). Contrary to hypotheses, 1-hydroxynaphthalene was associated with lower risk for Behavior Problems at age 2 (RR = 0.90, 95% CI: 0.83,0.98), and combined 1- and 9-hydroxyphenanthrene was associated with 0.52-point higher (95% CI: 0.11,0.93) Cognitive score at age 3. For PAH mixtures, a quintile increase in hydroxy-PAH mixture was associated with lower Language score at age 2 (βwqs = −1.59; 95% CI: −2.84, −0.34; ppermutation = 0.07) and higher Cognitive score at age 3 (βwqs = 0.96; 95% CI: 0.11, 1.82; ppermutation = 0.05). All other estimates were consistent with null associations. Conclusion: In this large southern U.S. population we observed some support for adverse associations between PAHs and neurodevelopment. |
| first_indexed | 2024-12-18T05:10:01Z |
| format | Article |
| id | doaj.art-39a9cff16ea24e82a2f4f15a9a3e3024 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-18T05:10:01Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-39a9cff16ea24e82a2f4f15a9a3e30242022-12-21T21:19:54ZengElsevierEnvironment International0160-41202022-01-01159107039Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behaviorErin R. Wallace0Yu Ni1Christine T. Loftus2Alexis Sullivan3Erin Masterson4Adam A. Szpiro5Drew B. Day6Morgan Robinson7Kurunthachalam Kannan8Fran A. Tylavsky9Sheela Sathyanarayana10Nicole R. Bush11Kaja Z. LeWinn12Catherine J. Karr13Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Corresponding author at: Department of Environmental and Occupational Health Sciences, University of Washington, Roosevelt One Building, Box 354695, 4225 Roosevelt Way NE, Seattle, WA 98105, USA.Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Psychiatry, School of Medicine, University of California, San Francisco, San Francisco, CA, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USADepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USASeattle Children’s Research Institute, Seattle, WA, USADepartment of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USADepartment of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USADepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Seattle Children’s Research Institute, Seattle, WA, USA; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USADepartment of Psychiatry, School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USADepartment of Psychiatry, School of Medicine, University of California, San Francisco, San Francisco, CA, USADepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USABackground: Animal and epidemiological studies suggest that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may negatively impact toddler neurodevelopment. Methods: We investigated this association in 835 mother–child pairs from CANDLE, a diverse pregnancy cohort in the mid-South region of the U.S. PAH metabolite concentrations were measured in mid-pregnancy maternal urine. Cognitive and Language composite scores at ages 2 and 3 years were derived from the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-3). Behavior Problem and Competence scores at age 2 were derived from the Brief Infant and Toddler Social Emotional Assessment (BITSEA). We used multivariate linear or Poisson regression to estimate associations with continuous scores and relative risks (RR) of neurodevelopment delay or behavior problems per 2-fold increase in PAH, adjusted for maternal health, nutrition, and socioeconomic status. Secondary analyses investigated associations with PAH mixture using Weighted Quantile Sum Regression (WQS) with a permutation test extension. Results: 1- hydroxypyrene was associated with elevated relative risk for Neurodevelopmental Delay at age 2 (RR = 1.20, 95% CI: 1.03,1.39). Contrary to hypotheses, 1-hydroxynaphthalene was associated with lower risk for Behavior Problems at age 2 (RR = 0.90, 95% CI: 0.83,0.98), and combined 1- and 9-hydroxyphenanthrene was associated with 0.52-point higher (95% CI: 0.11,0.93) Cognitive score at age 3. For PAH mixtures, a quintile increase in hydroxy-PAH mixture was associated with lower Language score at age 2 (βwqs = −1.59; 95% CI: −2.84, −0.34; ppermutation = 0.07) and higher Cognitive score at age 3 (βwqs = 0.96; 95% CI: 0.11, 1.82; ppermutation = 0.05). All other estimates were consistent with null associations. Conclusion: In this large southern U.S. population we observed some support for adverse associations between PAHs and neurodevelopment.http://www.sciencedirect.com/science/article/pii/S0160412021006644Polycyclic aromatic hydrocarbonsPediatric neurodevelopmentPrenatal |
| spellingShingle | Erin R. Wallace Yu Ni Christine T. Loftus Alexis Sullivan Erin Masterson Adam A. Szpiro Drew B. Day Morgan Robinson Kurunthachalam Kannan Fran A. Tylavsky Sheela Sathyanarayana Nicole R. Bush Kaja Z. LeWinn Catherine J. Karr Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior Environment International Polycyclic aromatic hydrocarbons Pediatric neurodevelopment Prenatal |
| title | Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior |
| title_full | Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior |
| title_fullStr | Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior |
| title_full_unstemmed | Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior |
| title_short | Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior |
| title_sort | prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition language and behavior |
| topic | Polycyclic aromatic hydrocarbons Pediatric neurodevelopment Prenatal |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021006644 |
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