<i>Cryptococcus neoformans</i> Prp8 Intein: An In Vivo Target-Based Drug Screening System in <i>Saccharomyces cerevisiae</i> to Identify Protein Splicing Inhibitors and Explore Its Dynamics

<i>Cryptococcus neoformans</i> Prp8 Intein: An In Vivo Target-Based Drug Screening System in <i>Saccharomyces cerevisiae</i> to Identify Protein Splicing Inhibitors and Explore Its Dynamics

Inteins are genetic mobile elements that are inserted within protein-coding genes, which are usually housekeeping genes. They are transcribed and translated along with the host gene, then catalyze their own splicing out of the host protein, which assumes its functional conformation thereafter. As Pr...

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Bibliographic Details
Main Authors: José Alex Lourenço Fernandes, Matheus da Silva Zatti, Thales Domingos Arantes, Maria Fernanda Bezerra de Souza, Mariana Marchi Santoni, Danuza Rossi, Cleslei Fernando Zanelli, Xiang-Qin Liu, Eduardo Bagagli, Raquel Cordeiro Theodoro
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Journal of Fungi
Subjects:
protein splicing
intein
Prp8
Ura3
CnePrp8i
cisplatin
Online Access:https://www.mdpi.com/2309-608X/8/8/846

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