Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature Review

Background: Vaccine hesitancy was labelled as one of the top ten threats to global health by the World Health Organization in 2019 and is associated with negative health outcomes. Previous reviews on cause of vaccines have not included vaccine hesitancy related to the COVID-19 vaccine. This review a...

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Main Authors: Simran Kumar, Zayna Shah, Sara Garfield
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/10/9/1518
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author Simran Kumar
Zayna Shah
Sara Garfield
author_facet Simran Kumar
Zayna Shah
Sara Garfield
author_sort Simran Kumar
collection DOAJ
description Background: Vaccine hesitancy was labelled as one of the top ten threats to global health by the World Health Organization in 2019 and is associated with negative health outcomes. Previous reviews on cause of vaccines have not included vaccine hesitancy related to the COVID-19 vaccine. This review aimed to fill this gap by synthesising the findings of studies identifying causes of vaccine hesitancy to the COVID-19 and influenza vaccines. Methods: A systematic literature review was conducted. Searches were carried out in the PubMed, EMBASE and Cochrane databases. Following data extraction, a thematic analysis was conducted of the causes of vaccine hesitancy in adults for the influenza and COVID-19 vaccines. Results: Fourteen papers were included. Four themes were identified as causes of vaccine hesitancy comprising: concerns over safety, lack of trust, lack of need for vaccination and cultural reasons. While concerns over safety were found in all countries, some of these were specific to particular countries and cultures. Our findings suggest that scientific knowledge of vaccines and size of clinical trials during their development reduce vaccine hesitancy. However, pharmaceutical companies were not a trusted source of information. Conclusion: Our findings build on those of previous research to suggest specific information that may be helpful in addressing vaccine hesitancy. Targeted approaches from trusted sources are needed to address specific safety concerns.
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spelling doaj.art-39ac804d991042cabc23912cf1b6ec762023-11-23T19:22:29ZengMDPI AGVaccines2076-393X2022-09-01109151810.3390/vaccines10091518Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature ReviewSimran Kumar0Zayna Shah1Sara Garfield2University College London School of Pharmacy, London WC1N 1AX, UKUniversity College London School of Pharmacy, London WC1N 1AX, UKUniversity College London School of Pharmacy, London WC1N 1AX, UKBackground: Vaccine hesitancy was labelled as one of the top ten threats to global health by the World Health Organization in 2019 and is associated with negative health outcomes. Previous reviews on cause of vaccines have not included vaccine hesitancy related to the COVID-19 vaccine. This review aimed to fill this gap by synthesising the findings of studies identifying causes of vaccine hesitancy to the COVID-19 and influenza vaccines. Methods: A systematic literature review was conducted. Searches were carried out in the PubMed, EMBASE and Cochrane databases. Following data extraction, a thematic analysis was conducted of the causes of vaccine hesitancy in adults for the influenza and COVID-19 vaccines. Results: Fourteen papers were included. Four themes were identified as causes of vaccine hesitancy comprising: concerns over safety, lack of trust, lack of need for vaccination and cultural reasons. While concerns over safety were found in all countries, some of these were specific to particular countries and cultures. Our findings suggest that scientific knowledge of vaccines and size of clinical trials during their development reduce vaccine hesitancy. However, pharmaceutical companies were not a trusted source of information. Conclusion: Our findings build on those of previous research to suggest specific information that may be helpful in addressing vaccine hesitancy. Targeted approaches from trusted sources are needed to address specific safety concerns.https://www.mdpi.com/2076-393X/10/9/1518vaccine hesitancyadultsinfluenzaCOVID-19
spellingShingle Simran Kumar
Zayna Shah
Sara Garfield
Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature Review
Vaccines
vaccine hesitancy
adults
influenza
COVID-19
title Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature Review
title_full Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature Review
title_fullStr Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature Review
title_full_unstemmed Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature Review
title_short Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature Review
title_sort causes of vaccine hesitancy in adults for the influenza and covid 19 vaccines a systematic literature review
topic vaccine hesitancy
adults
influenza
COVID-19
url https://www.mdpi.com/2076-393X/10/9/1518
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AT saragarfield causesofvaccinehesitancyinadultsfortheinfluenzaandcovid19vaccinesasystematicliteraturereview