Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
TRPV2 is activated by temperature and cannabinoids. Here, the authors have used cryo-EM and electrophysiology to identify a cannabinoid binding site distinct from that of cannabidiol as a possible drug target for treatment of inflammation and immune-mediated diseases.
Main Authors: | Liying Zhang, Charlotte Simonsen, Lucie Zimova, Kaituo Wang, Lavanya Moparthi, Rachelle Gaudet, Maria Ekoff, Gunnar Nilsson, Ute A. Hellmich, Viktorie Vlachova, Pontus Gourdon, Peter M. Zygmunt |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-35163-y |
Similar Items
-
The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain
by: Lavanya Moparthi, et al.
Published: (2022-10-01) -
Phospho-Mimetic Mutation at Ser602 Inactivates Human TRPA1 Channel
by: Kristyna Barvikova, et al.
Published: (2020-10-01) -
Activity dependent inhibition of TRPC1/4/5 channels by duloxetine involves voltage sensor-like domain
by: Lucie Zimova, et al.
Published: (2022-08-01) -
Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage
by: Viktor Sinica, et al.
Published: (2019-12-01) -
Cannabidiol and Other Cannabinoids in Demyelinating Diseases
by: Carmen Navarrete, et al.
Published: (2021-03-01)