Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance
Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2018.00144/full |
| _version_ | 1818621299282411520 |
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| author | Andrea del Campo Andrea del Campo Andrea del Campo Catalina Bustos Carolina Mascayano Claudio Acuña-Castillo Claudio Acuña-Castillo Rodrigo Troncoso Leonel E. Rojo Leonel E. Rojo |
| author_facet | Andrea del Campo Andrea del Campo Andrea del Campo Catalina Bustos Carolina Mascayano Claudio Acuña-Castillo Claudio Acuña-Castillo Rodrigo Troncoso Leonel E. Rojo Leonel E. Rojo |
| author_sort | Andrea del Campo |
| collection | DOAJ |
| description | Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, in part because the molecular mechanisms underlying SGAs toxicity are not yet completely elucidated. In this perspective article, we introduce an innovative approach to study the metabolic side effects of antipsychotics through the alterations of the mitochondrial dynamics, which leads to an imbalance in mitochondrial fusion/fission ratio and to an inefficient mitochondrial phenotype of muscle cells. We believe that this approach may offer a valuable path to explain SGAs-induced alterations in metabolic homeostasis. |
| first_indexed | 2024-12-16T18:07:04Z |
| format | Article |
| id | doaj.art-39b07853024348e3914181144796d1b3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-16T18:07:04Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-39b07853024348e3914181144796d1b32022-12-21T22:21:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-04-01910.3389/fendo.2018.00144316281Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion ImbalanceAndrea del Campo0Andrea del Campo1Andrea del Campo2Catalina Bustos3Carolina Mascayano4Claudio Acuña-Castillo5Claudio Acuña-Castillo6Rodrigo Troncoso7Leonel E. Rojo8Leonel E. Rojo9Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, ChileEscuela de Química y Farmacia, Facultad de Ingeniería, Ciencia y Tecnología, Universidad Bernardo O’Higgins, Santiago, ChilePrograma de Biología Celular y Molecular, Facultad de Medicina, Universidad de Chile, Santiago, ChileDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, ChileDepartamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, ChileDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, ChileCentro de Biotecnología Acuícola, Universidad de Santiago de Chile, Santiago, ChileLaboratorio de Investigación en Nutrición y Actividad Física, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, ChileCentro de Biotecnología Acuícola, Universidad de Santiago de Chile, Santiago, ChileSecond-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, in part because the molecular mechanisms underlying SGAs toxicity are not yet completely elucidated. In this perspective article, we introduce an innovative approach to study the metabolic side effects of antipsychotics through the alterations of the mitochondrial dynamics, which leads to an imbalance in mitochondrial fusion/fission ratio and to an inefficient mitochondrial phenotype of muscle cells. We believe that this approach may offer a valuable path to explain SGAs-induced alterations in metabolic homeostasis.http://journal.frontiersin.org/article/10.3389/fendo.2018.00144/fullsecond-generation antipsychotic agentsmitochondrial dynamicsinsulin resistanceL6 muscle cellsobesity |
| spellingShingle | Andrea del Campo Andrea del Campo Andrea del Campo Catalina Bustos Carolina Mascayano Claudio Acuña-Castillo Claudio Acuña-Castillo Rodrigo Troncoso Leonel E. Rojo Leonel E. Rojo Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance Frontiers in Endocrinology second-generation antipsychotic agents mitochondrial dynamics insulin resistance L6 muscle cells obesity |
| title | Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance |
| title_full | Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance |
| title_fullStr | Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance |
| title_full_unstemmed | Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance |
| title_short | Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance |
| title_sort | metabolic syndrome and antipsychotics the role of mitochondrial fission fusion imbalance |
| topic | second-generation antipsychotic agents mitochondrial dynamics insulin resistance L6 muscle cells obesity |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2018.00144/full |
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