Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance

Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance

Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, i...

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Bibliographic Details
Main Authors: Andrea del Campo, Catalina Bustos, Carolina Mascayano, Claudio Acuña-Castillo, Rodrigo Troncoso, Leonel E. Rojo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Endocrinology
Subjects:
second-generation antipsychotic agents
mitochondrial dynamics
insulin resistance
L6 muscle cells
obesity
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00144/full

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