Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions
Here we report the development of new drug carriers for meropenem based on the hydroxypropyl-β-cyclodextrin (HPCD) polymers with variable linkers, namely, 1,6-hexamethylenediisocyanate (HMD), citric acid (CA), succinic anhydride (SA). The structures of obtained polyesters and polyurethanes nanoparti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/6/3608 |
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| author | Linara R. Yakupova Anna A. Skuredina Pavel O. Markov Irina M. Le-Deygen Elena V. Kudryashova |
| author_facet | Linara R. Yakupova Anna A. Skuredina Pavel O. Markov Irina M. Le-Deygen Elena V. Kudryashova |
| author_sort | Linara R. Yakupova |
| collection | DOAJ |
| description | Here we report the development of new drug carriers for meropenem based on the hydroxypropyl-β-cyclodextrin (HPCD) polymers with variable linkers, namely, 1,6-hexamethylenediisocyanate (HMD), citric acid (CA), succinic anhydride (SA). The structures of obtained polyesters and polyurethanes nanoparticles (120–200 nm) were investigated by NMR and FTIR-spectroscopy. The PXRD pattern demonstrated that HPCD polymers form complexes with meropenem (MP), and the majority of MP molecules are encapsulated into a complex. MP’s imprinting in the HPCD-HMD polymer matrix lead to an encapsulation efficiency of up to 82%. HPCD-HMD and HPCD-SA polymers increase MP’s stability during the storage of its aqueous solution (in 1.4 and 1.2 times, respectively). In contrast, HPCD-CA polymer negatively affects MP’s stability. In prospect, the HPCD-HMD polymer may be promising for the development of a highly efficient drug delivery system for MP. |
| first_indexed | 2024-03-11T06:58:23Z |
| format | Article |
| id | doaj.art-39b0ba69ebb44a56ad423415bfd40c9f |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T06:58:23Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-39b0ba69ebb44a56ad423415bfd40c9f2023-11-17T09:24:12ZengMDPI AGApplied Sciences2076-34172023-03-01136360810.3390/app13063608Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem SolutionsLinara R. Yakupova0Anna A. Skuredina1Pavel O. Markov2Irina M. Le-Deygen3Elena V. Kudryashova4Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, RussiaChemistry Department, Lomonosov Moscow State University, 119991 Moscow, RussiaChemistry Department, Lomonosov Moscow State University, 119991 Moscow, RussiaChemistry Department, Lomonosov Moscow State University, 119991 Moscow, RussiaChemistry Department, Lomonosov Moscow State University, 119991 Moscow, RussiaHere we report the development of new drug carriers for meropenem based on the hydroxypropyl-β-cyclodextrin (HPCD) polymers with variable linkers, namely, 1,6-hexamethylenediisocyanate (HMD), citric acid (CA), succinic anhydride (SA). The structures of obtained polyesters and polyurethanes nanoparticles (120–200 nm) were investigated by NMR and FTIR-spectroscopy. The PXRD pattern demonstrated that HPCD polymers form complexes with meropenem (MP), and the majority of MP molecules are encapsulated into a complex. MP’s imprinting in the HPCD-HMD polymer matrix lead to an encapsulation efficiency of up to 82%. HPCD-HMD and HPCD-SA polymers increase MP’s stability during the storage of its aqueous solution (in 1.4 and 1.2 times, respectively). In contrast, HPCD-CA polymer negatively affects MP’s stability. In prospect, the HPCD-HMD polymer may be promising for the development of a highly efficient drug delivery system for MP.https://www.mdpi.com/2076-3417/13/6/3608cyclodextrin polymersmeropenemdrug delivery |
| spellingShingle | Linara R. Yakupova Anna A. Skuredina Pavel O. Markov Irina M. Le-Deygen Elena V. Kudryashova Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions Applied Sciences cyclodextrin polymers meropenem drug delivery |
| title | Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions |
| title_full | Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions |
| title_fullStr | Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions |
| title_full_unstemmed | Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions |
| title_short | Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions |
| title_sort | cyclodextrin polymers as a promising drug carriers for stabilization of meropenem solutions |
| topic | cyclodextrin polymers meropenem drug delivery |
| url | https://www.mdpi.com/2076-3417/13/6/3608 |
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