Osteonecrosis of the Jaw
Osteonecrosis of the jaw is a condition in which bone cells die due to various causes. It is classified as drug-induced jaw osteonecrosis, osteoradionecrosis, traumatic, non-traumatic, and spontaneous osteonecrosis. Antiresorptive or antiangiogenic drugs cause drug-induced osteonecrosis. The combina...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/11/1/23 |
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| author | Božana Lončar Brzak Lorena Horvat Aleksijević Ema Vindiš Iva Kordić Marko Granić Danica Vidović Juras Ana Andabak Rogulj |
| author_facet | Božana Lončar Brzak Lorena Horvat Aleksijević Ema Vindiš Iva Kordić Marko Granić Danica Vidović Juras Ana Andabak Rogulj |
| author_sort | Božana Lončar Brzak |
| collection | DOAJ |
| description | Osteonecrosis of the jaw is a condition in which bone cells die due to various causes. It is classified as drug-induced jaw osteonecrosis, osteoradionecrosis, traumatic, non-traumatic, and spontaneous osteonecrosis. Antiresorptive or antiangiogenic drugs cause drug-induced osteonecrosis. The combination of medications, microbial contamination, and local trauma induces this condition. Osteoradionecrosis is a severe radiation therapy side effect that can affect people with head and neck cancer. It is described as an exposed bone area that does not heal for longer than three months after the end of radiation treatment with the absence of any indications of an original tumor, recurrence, or metastasis. Trauma (tooth extraction), tumor site, radiation dose that the patient receives, the area of the bone which is irradiated, oral hygiene, and other factors are risk factors for the development of osteonecrosis. Less frequently, osteonecrosis can also be induced by non-traumatic and traumatic causes. Non-traumatic osteonecrosis is brought on by infections, acquired and congenital disorders, as well as the impact of chemicals. Traumatic osteonecrosis is brought on by thermal, mechanical, or chemical damage. The treatment of osteonecrosis can be conservative, which aims to be beneficial for the patient’s quality of life, and surgical, which involves debridement of the necrotic bone. |
| first_indexed | 2024-03-09T13:03:35Z |
| format | Article |
| id | doaj.art-39b2d2fafb52400181c2db1ef767742b |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-09T13:03:35Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-39b2d2fafb52400181c2db1ef767742b2023-11-30T21:51:07ZengMDPI AGDentistry Journal2304-67672023-01-011112310.3390/dj11010023Osteonecrosis of the JawBožana Lončar Brzak0Lorena Horvat Aleksijević1Ema Vindiš2Iva Kordić3Marko Granić4Danica Vidović Juras5Ana Andabak Rogulj6Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaFaculty of Dental Medicine and Health, University of Osijek, 31000 Osijek, CroatiaDental Practice at Healthcare Center Ormož, 2270 Ormož, SloveniaIndependent Researcher, 10000 Zagreb, CroatiaDepartment of Oral Surgery, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaOsteonecrosis of the jaw is a condition in which bone cells die due to various causes. It is classified as drug-induced jaw osteonecrosis, osteoradionecrosis, traumatic, non-traumatic, and spontaneous osteonecrosis. Antiresorptive or antiangiogenic drugs cause drug-induced osteonecrosis. The combination of medications, microbial contamination, and local trauma induces this condition. Osteoradionecrosis is a severe radiation therapy side effect that can affect people with head and neck cancer. It is described as an exposed bone area that does not heal for longer than three months after the end of radiation treatment with the absence of any indications of an original tumor, recurrence, or metastasis. Trauma (tooth extraction), tumor site, radiation dose that the patient receives, the area of the bone which is irradiated, oral hygiene, and other factors are risk factors for the development of osteonecrosis. Less frequently, osteonecrosis can also be induced by non-traumatic and traumatic causes. Non-traumatic osteonecrosis is brought on by infections, acquired and congenital disorders, as well as the impact of chemicals. Traumatic osteonecrosis is brought on by thermal, mechanical, or chemical damage. The treatment of osteonecrosis can be conservative, which aims to be beneficial for the patient’s quality of life, and surgical, which involves debridement of the necrotic bone.https://www.mdpi.com/2304-6767/11/1/23drug-induced osteonecrosisosteonecrosisosteoradionecrosisradiotherapy |
| spellingShingle | Božana Lončar Brzak Lorena Horvat Aleksijević Ema Vindiš Iva Kordić Marko Granić Danica Vidović Juras Ana Andabak Rogulj Osteonecrosis of the Jaw Dentistry Journal drug-induced osteonecrosis osteonecrosis osteoradionecrosis radiotherapy |
| title | Osteonecrosis of the Jaw |
| title_full | Osteonecrosis of the Jaw |
| title_fullStr | Osteonecrosis of the Jaw |
| title_full_unstemmed | Osteonecrosis of the Jaw |
| title_short | Osteonecrosis of the Jaw |
| title_sort | osteonecrosis of the jaw |
| topic | drug-induced osteonecrosis osteonecrosis osteoradionecrosis radiotherapy |
| url | https://www.mdpi.com/2304-6767/11/1/23 |
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