Two-Component Systems in Francisella Species
Bacteria alter gene expression in response to changes in their environment through various mechanisms that include signal transduction systems. These signal transduction systems use membrane histidine kinase with sensing domains to mediate phosphotransfer to DNA-binding proteins that alter the level...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2019.00198/full |
| _version_ | 1811325831116488704 |
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| author | Monique L. van Hoek Ky V. Hoang Ky V. Hoang John S. Gunn John S. Gunn John S. Gunn |
| author_facet | Monique L. van Hoek Ky V. Hoang Ky V. Hoang John S. Gunn John S. Gunn John S. Gunn |
| author_sort | Monique L. van Hoek |
| collection | DOAJ |
| description | Bacteria alter gene expression in response to changes in their environment through various mechanisms that include signal transduction systems. These signal transduction systems use membrane histidine kinase with sensing domains to mediate phosphotransfer to DNA-binding proteins that alter the level of gene expression. Such regulators are called two-component systems (TCSs). TCSs integrate external signals and information from stress pathways, central metabolism and other global regulators, thus playing an important role as part of the overall regulatory network. This review will focus on the knowledge of TCSs in the Gram-negative bacterium, Francisella tularensis, a biothreat agent with a wide range of potential hosts and a significant ability to cause disease. While TCSs have been well-studied in several bacterial pathogens, they have not been well-studied in non-model organisms, such as F. tularensis and its subspecies, whose canonical TCS content surprisingly ranges from few to none. Additionally, of those TCS genes present, many are orphan components, including KdpDE, QseC, QseB/PmrA, and an unnamed two-component system (FTN_1452/FTN_1453). We discuss recent advances in this field related to the role of TCSs in Francisella physiology and pathogenesis and compare the TCS genes present in human virulent versus. environmental species and subspecies of Francisella. |
| first_indexed | 2024-04-13T14:40:26Z |
| format | Article |
| id | doaj.art-39b3299e7451478e9cbc9b9152eaa6c0 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T14:40:26Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-39b3299e7451478e9cbc9b9152eaa6c02022-12-22T02:42:55ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882019-06-01910.3389/fcimb.2019.00198464880Two-Component Systems in Francisella SpeciesMonique L. van Hoek0Ky V. Hoang1Ky V. Hoang2John S. Gunn3John S. Gunn4John S. Gunn5School of Systems Biology, George Mason University, Manassas, VA, United StatesCenter for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, OH, United StatesInfectious Diseases Institute, The Ohio State University, Columbus, OH, United StatesCenter for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, OH, United StatesInfectious Diseases Institute, The Ohio State University, Columbus, OH, United StatesDepartment of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, United StatesBacteria alter gene expression in response to changes in their environment through various mechanisms that include signal transduction systems. These signal transduction systems use membrane histidine kinase with sensing domains to mediate phosphotransfer to DNA-binding proteins that alter the level of gene expression. Such regulators are called two-component systems (TCSs). TCSs integrate external signals and information from stress pathways, central metabolism and other global regulators, thus playing an important role as part of the overall regulatory network. This review will focus on the knowledge of TCSs in the Gram-negative bacterium, Francisella tularensis, a biothreat agent with a wide range of potential hosts and a significant ability to cause disease. While TCSs have been well-studied in several bacterial pathogens, they have not been well-studied in non-model organisms, such as F. tularensis and its subspecies, whose canonical TCS content surprisingly ranges from few to none. Additionally, of those TCS genes present, many are orphan components, including KdpDE, QseC, QseB/PmrA, and an unnamed two-component system (FTN_1452/FTN_1453). We discuss recent advances in this field related to the role of TCSs in Francisella physiology and pathogenesis and compare the TCS genes present in human virulent versus. environmental species and subspecies of Francisella.https://www.frontiersin.org/article/10.3389/fcimb.2019.00198/fulltwo-component system (TCS)Francisellaresponse regulatorsensor histidine kinaseQseCQseB |
| spellingShingle | Monique L. van Hoek Ky V. Hoang Ky V. Hoang John S. Gunn John S. Gunn John S. Gunn Two-Component Systems in Francisella Species Frontiers in Cellular and Infection Microbiology two-component system (TCS) Francisella response regulator sensor histidine kinase QseC QseB |
| title | Two-Component Systems in Francisella Species |
| title_full | Two-Component Systems in Francisella Species |
| title_fullStr | Two-Component Systems in Francisella Species |
| title_full_unstemmed | Two-Component Systems in Francisella Species |
| title_short | Two-Component Systems in Francisella Species |
| title_sort | two component systems in francisella species |
| topic | two-component system (TCS) Francisella response regulator sensor histidine kinase QseC QseB |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2019.00198/full |
| work_keys_str_mv | AT moniquelvanhoek twocomponentsystemsinfrancisellaspecies AT kyvhoang twocomponentsystemsinfrancisellaspecies AT kyvhoang twocomponentsystemsinfrancisellaspecies AT johnsgunn twocomponentsystemsinfrancisellaspecies AT johnsgunn twocomponentsystemsinfrancisellaspecies AT johnsgunn twocomponentsystemsinfrancisellaspecies |