Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study
Adverse drug events (ADEs) are a major public health concern, given their consequences in terms of morbi-mortality and associated healthcare costs. Many studies have focused on the elderly, who are considered particularly vulnerable in this respect. We aimed to determine and compare the frequency, c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/19/5731 |
| _version_ | 1797478610420891648 |
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| author | Laura Lohan Grégory Marin Marie Faucanie Marion Laureau Damien Perier Véronique Pinzani Isabelle Giraud Maxime Villiet Mustapha Sebbane Ariane Sultan Cyril Breuker |
| author_facet | Laura Lohan Grégory Marin Marie Faucanie Marion Laureau Damien Perier Véronique Pinzani Isabelle Giraud Maxime Villiet Mustapha Sebbane Ariane Sultan Cyril Breuker |
| author_sort | Laura Lohan |
| collection | DOAJ |
| description | Adverse drug events (ADEs) are a major public health concern, given their consequences in terms of morbi-mortality and associated healthcare costs. Many studies have focused on the elderly, who are considered particularly vulnerable in this respect. We aimed to determine and compare the frequency, characteristics, and predictive factors of ADEs according to age in an adult population. A prospective seven-year cross-sectional study was conducted in a university hospital emergency department. Structured medication reviews and ADE detection were performed. Patient data and ADE characteristics were collected. Descriptive statistics and logistic regression were performed in two age groups: Group 1 (age < 65 years) and 2 (age ≥ 65 years). Among the 13,653 patients included, 18.4% in Group 1 and 22.6% in Group 2 experienced an ADE. Differences were identified in terms of the ADE type (more ADEs due to noncompliance in Group 1) and ADE symptoms (greater bleeding in Group 2). In the multivariable analysis, several specific predictive factors were identified, including kidney failure and antidiabetic drug use in Group 1 and inappropriate prescription and antithrombotic treatment in Group 2. Analysis by age provided a more refined vision of ADEs as we identified distinct profiles of iatrogenesis. These results will lead to a better detection of ADEs. |
| first_indexed | 2024-03-09T21:34:09Z |
| format | Article |
| id | doaj.art-39b34186f2cd4c1eb969d51cfebfca8a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:34:09Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-39b34186f2cd4c1eb969d51cfebfca8a2023-11-23T20:47:51ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011119573110.3390/jcm11195731Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional StudyLaura Lohan0Grégory Marin1Marie Faucanie2Marion Laureau3Damien Perier4Véronique Pinzani5Isabelle Giraud6Maxime Villiet7Mustapha Sebbane8Ariane Sultan9Cyril Breuker10Clinical Pharmacy Department, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceClinical Research and Epidemiology Unit, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceClinical Research and Epidemiology Unit, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceClinical Pharmacy Department, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceEmergency Medicine Department, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceMedical Pharmacology and Toxicology Department, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceEconomic Evaluation Unit, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceClinical Pharmacy Department, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceEmergency Medicine Department, CHU Montpellier, University of Montpellier, 34295 Montpellier, FrancePhyMedExp, University of Montpellier, CNRS, INSERM, 34000 Montpellier, FranceClinical Pharmacy Department, CHU Montpellier, University of Montpellier, 34295 Montpellier, FranceAdverse drug events (ADEs) are a major public health concern, given their consequences in terms of morbi-mortality and associated healthcare costs. Many studies have focused on the elderly, who are considered particularly vulnerable in this respect. We aimed to determine and compare the frequency, characteristics, and predictive factors of ADEs according to age in an adult population. A prospective seven-year cross-sectional study was conducted in a university hospital emergency department. Structured medication reviews and ADE detection were performed. Patient data and ADE characteristics were collected. Descriptive statistics and logistic regression were performed in two age groups: Group 1 (age < 65 years) and 2 (age ≥ 65 years). Among the 13,653 patients included, 18.4% in Group 1 and 22.6% in Group 2 experienced an ADE. Differences were identified in terms of the ADE type (more ADEs due to noncompliance in Group 1) and ADE symptoms (greater bleeding in Group 2). In the multivariable analysis, several specific predictive factors were identified, including kidney failure and antidiabetic drug use in Group 1 and inappropriate prescription and antithrombotic treatment in Group 2. Analysis by age provided a more refined vision of ADEs as we identified distinct profiles of iatrogenesis. These results will lead to a better detection of ADEs.https://www.mdpi.com/2077-0383/11/19/5731adverse drug eventepidemiology and detectionage factorsemergency departmentpatient safetyhealthcare quality improvement |
| spellingShingle | Laura Lohan Grégory Marin Marie Faucanie Marion Laureau Damien Perier Véronique Pinzani Isabelle Giraud Maxime Villiet Mustapha Sebbane Ariane Sultan Cyril Breuker Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study Journal of Clinical Medicine adverse drug event epidemiology and detection age factors emergency department patient safety healthcare quality improvement |
| title | Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study |
| title_full | Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study |
| title_fullStr | Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study |
| title_full_unstemmed | Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study |
| title_short | Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study |
| title_sort | frequency characteristics and predictive factors of adverse drug events in an adult emergency department according to age a cross sectional study |
| topic | adverse drug event epidemiology and detection age factors emergency department patient safety healthcare quality improvement |
| url | https://www.mdpi.com/2077-0383/11/19/5731 |
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