A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology
Invasive fungal diseases (IFDs) often represent complicated infections in complex patient populations. The Center of Expertise in Mycology Radboudumc/CWZ (EMRC) organizes a biweekly multidisciplinary mycology meeting to discuss patients with severe fungal infections and to provide comprehensive advi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/6/4/274 |
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| author | Nico A. F. Janssen Roger J. M. Brüggemann Monique H. Reijers Stefanie S. V. Henriet Jaap ten Oever Quirijn de Mast Yvonne Berk Elizabeth A. de Kort Bart Jan Kullberg Mihai G. Netea Jochem B. Buil Janette C. Rahamat-Langendoen Didi Bury Eline W. Muilwijk Jacques F. Meis Paul E. Verweij Frank L. van de Veerdonk |
| author_facet | Nico A. F. Janssen Roger J. M. Brüggemann Monique H. Reijers Stefanie S. V. Henriet Jaap ten Oever Quirijn de Mast Yvonne Berk Elizabeth A. de Kort Bart Jan Kullberg Mihai G. Netea Jochem B. Buil Janette C. Rahamat-Langendoen Didi Bury Eline W. Muilwijk Jacques F. Meis Paul E. Verweij Frank L. van de Veerdonk |
| author_sort | Nico A. F. Janssen |
| collection | DOAJ |
| description | Invasive fungal diseases (IFDs) often represent complicated infections in complex patient populations. The Center of Expertise in Mycology Radboudumc/CWZ (EMRC) organizes a biweekly multidisciplinary mycology meeting to discuss patients with severe fungal infections and to provide comprehensive advice regarding diagnosis and treatment. Here, we describe the patient population discussed at these meetings during a one-year period with regards to their past medical history, diagnosis, microbiological and other diagnostic test results and antifungal therapy. The majority of patients discussed were adults (83.1%), 62.5% of whom suffered from pulmonary infections or signs/symptoms, 10.9% from otorhinolaryngeal infections and/or oesophagitis, 9.4% from systemic infections and 9.4% from central nervous system infections. Among children, 53.8% had pulmonary infections or signs/symptoms, 23.1% systemic fungal infections and 23.1% other, miscellaneous fungal infections. 52.5% of adult patients with pulmonary infections/symptoms fulfilled diagnostic criteria for chronic pulmonary aspergillosis (CPA). Culture or polymerase chain reaction (PCR) demonstrated fungal pathogens in 81.8% of patients, most commonly <i>Aspergillus</i>. A multidisciplinary mycology meeting can be a useful addition to the care for patients with (I)FDs and can potentially aid in identifying healthcare and research needs regarding the field of fungal infections. The majority of patients discussed at the multidisciplinary meetings suffered from pulmonary infections, predominantly CPA. |
| first_indexed | 2024-03-10T14:57:41Z |
| format | Article |
| id | doaj.art-39b6af471081466c979734ba58264804 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T14:57:41Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-39b6af471081466c979734ba582648042023-11-20T20:23:46ZengMDPI AGJournal of Fungi2309-608X2020-11-016427410.3390/jof6040274A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in MycologyNico A. F. Janssen0Roger J. M. Brüggemann1Monique H. Reijers2Stefanie S. V. Henriet3Jaap ten Oever4Quirijn de Mast5Yvonne Berk6Elizabeth A. de Kort7Bart Jan Kullberg8Mihai G. Netea9Jochem B. Buil10Janette C. Rahamat-Langendoen11Didi Bury12Eline W. Muilwijk13Jacques F. Meis14Paul E. Verweij15Frank L. van de Veerdonk16Center of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Pulmonary Diseases, Canisius-Wilhelmina Hospital (CWZ), 6532 SZ Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsDepartment of Medical Microbiology, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Pharmacy, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Pharmacy, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsCenter of Expertise in Mycology Radboudumc/CWZ, 6525 GA Nijmegen, The NetherlandsInvasive fungal diseases (IFDs) often represent complicated infections in complex patient populations. The Center of Expertise in Mycology Radboudumc/CWZ (EMRC) organizes a biweekly multidisciplinary mycology meeting to discuss patients with severe fungal infections and to provide comprehensive advice regarding diagnosis and treatment. Here, we describe the patient population discussed at these meetings during a one-year period with regards to their past medical history, diagnosis, microbiological and other diagnostic test results and antifungal therapy. The majority of patients discussed were adults (83.1%), 62.5% of whom suffered from pulmonary infections or signs/symptoms, 10.9% from otorhinolaryngeal infections and/or oesophagitis, 9.4% from systemic infections and 9.4% from central nervous system infections. Among children, 53.8% had pulmonary infections or signs/symptoms, 23.1% systemic fungal infections and 23.1% other, miscellaneous fungal infections. 52.5% of adult patients with pulmonary infections/symptoms fulfilled diagnostic criteria for chronic pulmonary aspergillosis (CPA). Culture or polymerase chain reaction (PCR) demonstrated fungal pathogens in 81.8% of patients, most commonly <i>Aspergillus</i>. A multidisciplinary mycology meeting can be a useful addition to the care for patients with (I)FDs and can potentially aid in identifying healthcare and research needs regarding the field of fungal infections. The majority of patients discussed at the multidisciplinary meetings suffered from pulmonary infections, predominantly CPA.https://www.mdpi.com/2309-608X/6/4/274mycologyinvasive fungal diseasesmultidisciplinarydiagnosisantifungal treatment |
| spellingShingle | Nico A. F. Janssen Roger J. M. Brüggemann Monique H. Reijers Stefanie S. V. Henriet Jaap ten Oever Quirijn de Mast Yvonne Berk Elizabeth A. de Kort Bart Jan Kullberg Mihai G. Netea Jochem B. Buil Janette C. Rahamat-Langendoen Didi Bury Eline W. Muilwijk Jacques F. Meis Paul E. Verweij Frank L. van de Veerdonk A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology Journal of Fungi mycology invasive fungal diseases multidisciplinary diagnosis antifungal treatment |
| title | A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology |
| title_full | A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology |
| title_fullStr | A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology |
| title_full_unstemmed | A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology |
| title_short | A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology |
| title_sort | multidisciplinary approach to fungal infections one year experiences of a center of expertise in mycology |
| topic | mycology invasive fungal diseases multidisciplinary diagnosis antifungal treatment |
| url | https://www.mdpi.com/2309-608X/6/4/274 |
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