Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid.

Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid.

B10 is a glycosylated derivative of betulinic acid with promising activity against glioma cells. Lysosomal cell death pathways appear to be essential for its cytotoxicity. We investigated the influence of hypoxia, nutrient deprivation and current standard therapies on B10 cytotoxicity. The human gli...

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Bibliographic Details
Main Authors: Sebastian Fischer, Michael W Ronellenfitsch, Anna-Luisa Thiepold, Patrick N Harter, Sebastian Reichert, Donat Kögel, Reinhard Paschke, Michel Mittelbronn, Michael Weller, Joachim P Steinbach, Simone Fulda, Oliver Bähr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3990545?pdf=render

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http://europepmc.org/articles/PMC3990545?pdf=render

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