Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid.
B10 is a glycosylated derivative of betulinic acid with promising activity against glioma cells. Lysosomal cell death pathways appear to be essential for its cytotoxicity. We investigated the influence of hypoxia, nutrient deprivation and current standard therapies on B10 cytotoxicity. The human gli...
Main Authors: | Sebastian Fischer, Michael W Ronellenfitsch, Anna-Luisa Thiepold, Patrick N Harter, Sebastian Reichert, Donat Kögel, Reinhard Paschke, Michel Mittelbronn, Michael Weller, Joachim P Steinbach, Simone Fulda, Oliver Bähr |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3990545?pdf=render |
Similar Items
-
Antiglioma Potential of Coumarins Combined with Sorafenib
by: Joanna Sumorek-Wiadro, et al.
Published: (2020-11-01) -
Sensitization for Anticancer Drug-Induced Apoptosis by Betulinic Acid
by: Simone Fulda, et al.
Published: (2005-02-01) -
Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors.
by: Patrick N Harter, et al.
Published: (2015-01-01) -
Cetuximab-Mediated Protection from Hypoxia- Induced Cell Death: Implications for Therapy Sequence in Colorectal Cancer
by: Hans Urban, et al.
Published: (2020-10-01) -
Bioactive Compounds with Antiglioma Activity from Marine Species
by: Rodion Khotimchenko, et al.
Published: (2021-07-01)