Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer

Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer

Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies have shown that they increased binding affinity and signaling potency compared t...

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Bibliographic Details
Main Authors: Samman Mansoor, Gülru Kayık, Serdar Durdagi, Ozge Sensoy
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
G protein-coupled receptor
Heterobivalent ligand
Accelerated molecular dynamics
Oligomerization
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702200023X

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